(S)-4'-{2-[(2-hydroxy-3-phenoxypropyl)amino]ethyl}-2-(2-methylphenylaminothiazol-4-yl)acetanilide hydrochloride

Base Information

Chemical Name:(S)-4'-{2-[(2-hydroxy-3-phenoxypropyl)amino]ethyl}-2-(2-methylphenylaminothiazol-4-yl)acetanilide hydrochloride
CAS No.:211102-60-2
Molecular Formula:C₂₉H₃₂N₄O₃S*ClH
Molecular Weight:553.125
Hs Code.:

Synonyms:(S)-4'-{2-[(2-hydroxy-3-phenoxypropyl)amino]ethyl}-2-(2-methylphenylaminothiazol-4-yl)acetanilide hydrochloride

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Chemical Property of (S)-4'-{2-[(2-hydroxy-3-phenoxypropyl)amino]ethyl}-2-(2-methylphenylaminothiazol-4-yl)acetanilide hydrochloride

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Technology Process of (S)-4'-{2-[(2-hydroxy-3-phenoxypropyl)amino]ethyl}-2-(2-methylphenylaminothiazol-4-yl)acetanilide hydrochloride

There total 2 articles about (S)-4'-{2-[(2-hydroxy-3-phenoxypropyl)amino]ethyl}-2-(2-methylphenylaminothiazol-4-yl)acetanilide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 211103-41-2
tert-butyl (S)-N-(2-hydroxy-3-phenoxypropyl)-N-[2-(4-{[2-(2-methylphenylaminothiazol-4-yl)acetyl]amino}phenyl)ethyl]carbamate

: 211102-60-2
(S)-4'-{2-[(2-hydroxy-3-phenoxypropyl)amino]ethyl}-2-(2-methylphenylaminothiazol-4-yl)acetanilide hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; ethyl acetate; at 20 ℃;
DOI:10.1248/cpb.60.647

Reference yield:

: 56355-76-1
2-(methylphenylaminothiazol-4-yl)acetic acid

: 159183-36-5
tert-butyl (S)-N-[2-(4-aminophenyl)ethyl]-N-(2-hydroxy-3-phenoxy)propylcarbamate

: 211102-60-2
(S)-4'-{2-[(2-hydroxy-3-phenoxypropyl)amino]ethyl}-2-(2-methylphenylaminothiazol-4-yl)acetanilide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2: hydrogenchloride / methanol; ethyl acetate / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.60.647