Dibenzyl-[(R)-3-(4-benzyloxy-phenyl)-2-chloro-propyl]-amine

Base Information

• Chemical Name: Dibenzyl-[(R)-3-(4-benzyloxy-phenyl)-2-chloro-propyl]-amine
• CAS No.: 262590-66-9
• Molecular Formula: C₃₀H₃₀ClNO
• Molecular Weight: 456.027
• Mol file: 262590-66-9.mol

Synonyms:Dibenzyl-[(R)-3-(4-benzyloxy-phenyl)-2-chloro-propyl]-amine

Chemical Property of Dibenzyl-[(R)-3-(4-benzyloxy-phenyl)-2-chloro-propyl]-amine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of Dibenzyl-[(R)-3-(4-benzyloxy-phenyl)-2-chloro-propyl]-amine

There total 1 articles about Dibenzyl-[(R)-3-(4-benzyloxy-phenyl)-2-chloro-propyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(S)-3-(4-Benzyloxyphenyl)-2-(dibenzylamino)propan-1-ol (153290-53-0) → Dibenzyl-[(R)-3-(4-benzyloxy-phenyl)-2-chloro-propyl]-amine (262590-66-9)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/ol991402i

Reference yield: 74.0%

sodium cyanide (143-33-9,25596-52-5) + Dibenzyl-[(R)-3-(4-benzyloxy-phenyl)-2-chloro-propyl]-amine (262590-66-9) → (S)-4-(4-Benzyloxy-phenyl)-3-dibenzylamino-butyronitrile (262590-67-0)

Guidance literature:

In dimethyl sulfoxide; at 50 ℃; for 15h;

DOI:10.1021/ol991402i

Reference yield:

Dibenzyl-[(R)-3-(4-benzyloxy-phenyl)-2-chloro-propyl]-amine (262590-66-9) → N,N-dibenzyl-β-L-homotyrosine methyl ester (1024612-54-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / dimethylsulfoxide / 15 h / 50 °C

2: 84 percent / conc. HCl / 20 h / 80 °C

3: conc. HCl / 12 h / 80 °C

With hydrogenchloride; In dimethyl sulfoxide; 1: Substitution / 2: Hydrolysis / 3: Esterification;

DOI:10.1021/ol991402i

upstream raw materials:

(S)-3-(4-Benzyloxyphenyl)-2-(dibenzylamino)propan-1-ol

Downstream raw materials:

(S)-4-(4-Benzyloxy-phenyl)-3-dibenzylamino-butyronitrile

N,N-dibenzyl-β-L-homotyrosine methyl ester

N,N-dibenzyl-β-L-homotyrosine