2-(2,4-dimethoxybenzylamino)-3-(3-indolyl)-3-oxo-propionamide

Base Information

• Chemical Name: 2-(2,4-dimethoxybenzylamino)-3-(3-indolyl)-3-oxo-propionamide
• CAS No.: 255371-90-5
• Molecular Formula: C₂₀H₂₁N₃O₄
• Molecular Weight: 367.404
• Mol file: 255371-90-5.mol

Synonyms:2-(2,4-dimethoxybenzylamino)-3-(3-indolyl)-3-oxo-propionamide

Chemical Property of 2-(2,4-dimethoxybenzylamino)-3-(3-indolyl)-3-oxo-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-(2,4-dimethoxybenzylamino)-3-(3-indolyl)-3-oxo-propionamide

There total 1 articles about 2-(2,4-dimethoxybenzylamino)-3-(3-indolyl)-3-oxo-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

[1-carbamoyl-2-(3-indolyl)-2-oxoethyl]carbamic acid benzyl ester (255371-72-3) + 2,4-Dimethoxybenzaldehyde (613-45-6) → 2-(2,4-dimethoxybenzylamino)-3-(3-indolyl)-3-oxo-propionamide (255371-90-5)

Guidance literature:

[1-carbamoyl-2-(3-indolyl)-2-oxoethyl]carbamic acid benzyl ester; With hydrogen; palladium 10% on activated carbon; In ethanol; acetic acid; ethyl acetate; for 3h; under 760.051 Torr;

2,4-Dimethoxybenzaldehyde; With sodium tris(acetoxy)borohydride; In DMF (N,N-dimethyl-formamide); acetic acid; at 20 ℃; for 18h;

Reference yield: 63.0%

1-methyl-1H-indole-3-carbonyl azide (255372-17-9) + 2-(2,4-dimethoxybenzylamino)-3-(3-indolyl)-3-oxo-propionamide (255371-90-5) → 4-cyano-3-(2,4-dimethoxybenzyl)-5-(3-indolyl)-1-(1-methyl-3-indolyl)-2,3-dihydroimidazol-2-one (255371-91-6)

Guidance literature:

1-methyl-1H-indole-3-carbonyl azide; In benzene; for 5h; Heating / reflux;

2-(2,4-dimethoxybenzylamino)-3-(3-indolyl)-3-oxo-propionamide; In tetrahydrofuran; benzene; at 20 - 50 ℃; for 5h;

With TMS-polyphosphate; In dichloromethane; acetonitrile; for 1.5h; Heating / reflux;

upstream raw materials:

[1-carbamoyl-2-(3-indolyl)-2-oxoethyl]carbamic acid benzyl ester

2,4-Dimethoxybenzaldehyde

Downstream raw materials:

4-cyano-3-(2,4-dimethoxybenzyl)-5-(3-indolyl)-1-(1-methyl-3-indolyl)-2,3-dihydroimidazol-2-one