(Z)-7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)-N'-hydroxyheptanimidamide

Base Information

• Chemical Name: (Z)-7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)-N'-hydroxyheptanimidamide
• CAS No.: 1447693-81-3
• Molecular Formula: C₂₈H₃₅N₅O
• Molecular Weight: 457.619
• Mol file: 1447693-81-3.mol

Synonyms:(Z)-7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)-N'-hydroxyheptanimidamide

Chemical Property of (Z)-7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)-N'-hydroxyheptanimidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)-N'-hydroxyheptanimidamide

There total 3 articles about (Z)-7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)-N'-hydroxyheptanimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanenitrile (1447665-36-2) → (Z)-7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)-N'-hydroxyheptanimidamide (1447693-81-3)

Guidance literature:

With hydroxylamine hydrochloride; potassium carbonate; In ethanol; for 72h; Inert atmosphere; Reflux;

Reference yield:

7-oxoheptanenitrile (18214-15-8) → (Z)-7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)-N'-hydroxyheptanimidamide (1447693-81-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

2: potassium carbonate; hydroxylamine hydrochloride / ethanol / 72 h / Inert atmosphere; Reflux

With hydroxylamine hydrochloride; sodium tris(acetoxy)borohydride; potassium carbonate; In ethanol; 1,2-dichloro-ethane;

Reference yield:

7-bromo-heptanonitrile (20965-27-9) → (Z)-7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)-N'-hydroxyheptanimidamide (1447693-81-3)

Guidance literature:

Multi-step reaction with 3 steps

1: trimethylamine-N-oxide / dimethyl sulfoxide / 20 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C

3: potassium carbonate; hydroxylamine hydrochloride / ethanol / 72 h / Inert atmosphere; Reflux

With trimethylamine-N-oxide; hydroxylamine hydrochloride; sodium tris(acetoxy)borohydride; potassium carbonate; In ethanol; dimethyl sulfoxide; 1,2-dichloro-ethane;

upstream raw materials:

7-bromo-heptanonitrile

7-oxoheptanenitrile

7-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)heptanenitrile

Downstream raw materials:

3-(6-(2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-yl)hexyl)-1,2,4-oxadiazol-5(4H)-one

Refernces