prostaglandin A1

Base Information Edit

Chemical Name:prostaglandin A1
CAS No.:14152-28-4
Molecular Formula:C₂₀H₃₂O₄
Molecular Weight:336.472
Hs Code.:2937500000
European Community (EC) Number:682-017-9
UNII:VYR271N44P
ChEMBL ID:CHEMBL1084644
DSSTox Substance ID:DTXSID601347314
Metabolomics Workbench ID:2375
Nikkaji Number:J15.628K
Wikidata:Q27098093
Mol file:14152-28-4.mol

Synonyms:(13E,15S)-15-hydroxy-9-oxo-prosta-10,13-dien-1-oic acid;PGA1;prostaglandin A1;prostaglandin A1, (13E,15R)-(+-)-isomer;prostaglandin A1, (13E,15R)-isomer;prostaglandin A1, (13E,15S)-(+-)-isomer;prostaglandin A1, (8beta,12alpha,13E,15S)-isomer

Suppliers and Price of prostaglandin A1

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Prostaglandin A1
5mg
$ 470.00

Sigma-Aldrich
Prostaglandin A1 synthetic
5mg
$ 468.00

Sigma-Aldrich
Prostaglandin A1 synthetic
1mg
$ 135.00

Sigma-Aldrich
Prostaglandin A1 United States Pharmacopeia (USP) Reference Standard
25mg
$ 2970.00

Sigma-Aldrich
Prostaglandin A1 synthetic
10mg
$ 794.00

Medical Isotopes, Inc.
Prostaglandin A1
5 mg
$ 650.00

Cayman Chemical
Prostaglandin A1 ≥98%
5mg
$ 98.00

Cayman Chemical
Prostaglandin A1 ≥98%
1mg
$ 28.00

Cayman Chemical
Prostaglandin A1 ≥98%
50mg
$ 770.00

Cayman Chemical
Prostaglandin A1 ≥98%
10mg
$ 182.00

Total 22 raw suppliers

Chemical Property of prostaglandin A1 Edit

Chemical Property:

Appearance/Colour:white to yellow crystalline solid
Vapor Pressure:1.44E-12mmHg at 25°C
Melting Point:41 - 43 C
Refractive Index:1.4434 (estimate)
Boiling Point:510.7°Cat760mmHg
PKA:4.77±0.10(Predicted)
Flash Point:276.7°C
PSA：74.60000
Density:1.086g/cm³
LogP:4.28030
Storage Temp.:−20°C
Solubility.:acetone: 10 mg/mL, clear
XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:13
Exact Mass:336.23005950
Heavy Atom Count:24
Complexity:439

Purity/Quality:

98%,99%, ^*data from raw suppliers

Prostaglandin A1 ^*data from reagent suppliers

Safty Information:

Pictogram(s): UN NO.
Hazard Codes:UN NO.
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC(C=CC1C=CC(=O)C1CCCCCCC(=O)O)O
Isomeric SMILES:CCCCC[C@@H](/C=C/[C@H]1C=CC(=O)[C@@H]1CCCCCCC(=O)O)O
Description Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. It has been shown to cause renal vasodilation, increased urine sodium excretion, and lowered arterial pressure in hypertensive patients. It also has growth-inhibitory activity on tumor cells; the IC50 value for the inhibition of human ovarian cancer is 7.5 μM.
Uses Prostaglandin A1 has been shown to inhibit human immunodeficiency virus type 1 (HIV-1) replication in various cell types. In addition, as a precursor to the anti-inflammatory prostaglandins, it activates pro-inflammatory PGD2 receptor CRTH2 initiating the anti-inflammatory response.

Technology Process of prostaglandin A1

There total 7 articles about prostaglandin A1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: