Pseudouridine 5'-phosphate

Base Information

Chemical Name:Pseudouridine 5'-phosphate
CAS No.:1157-60-4
Molecular Formula:C₉H₁₃N₂O₉P
Molecular Weight:324.184
Hs Code.:
Nikkaji Number:J2.731.765K
Wikidata:Q27102833
Metabolomics Workbench ID:37698
Mol file:1157-60-4.mol

Synonyms:pseudouridylic acid

Suppliers and Price of Pseudouridine 5'-phosphate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 24 raw suppliers

Chemical Property of Pseudouridine 5'-phosphate

Chemical Property:

Vapor Pressure:2.7E-22mmHg at 25°C
Boiling Point:728.8°C at 760 mmHg
Flash Point:394.6°C
PSA：191.98000
Density:1.833g/cm³
LogP:-2.66580
XLogP3:-4.5
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:4
Exact Mass:324.03586699
Heavy Atom Count:21
Complexity:529

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=O)NC(=O)N1)C2C(C(C(O2)COP(=O)(O)O)O)O
Isomeric SMILES:C1=C(C(=O)NC(=O)N1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O
General Description Pseudouridine 5′-monophosphate (ψMP) is a modified nucleotide derived from pseudouridine (ψ), the most abundant RNA modification, which is first phosphorylated by ψ kinase and subsequently degraded by ψMP glycosidase into uracil and ribose 5-phosphate. ψMP glycosidase employs a unique C-C glycosidic bond cleavage mechanism involving a lysine adduct (Lys166 in *E. coli*) and proceeds via a ribose ring-opening intermediate, as evidenced by structural and biochemical studies. This enzymatic process represents a novel degradation pathway for pseudouridine derivatives.

Technology Process of Pseudouridine 5'-phosphate

There total 2 articles about Pseudouridine 5'-phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 93-87-8
D-ribose 5-phosphate

: 66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6
uracil

: 1157-60-4
pseudouridine 5'-monophosphate

Guidance literature:: With Escherichia coli ΨMP glycosidase; manganese(ll) chloride; In aq. buffer; at 25 ℃; for 1h; pH=7.1; Reagent/catalyst; Kinetics; Catalytic behavior; Enzymatic reaction;
DOI:10.1021/bi3006829