dibenzyl [3-(3-(allyloxy)-4-{(2S,3R)-1-^(4-)-3-[(3S)-3-{[tert-butyl(dimethyI)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}phenyl)prop-2-yn-1-yl]malonate

Base Information

• Chemical Name: dibenzyl [3-(3-(allyloxy)-4-{(2S,3R)-1-^(4-)-3-[(3S)-3-{[tert-butyl(dimethyI)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}phenyl)prop-2-yn-1-yl]malonate
• CAS No.: 1227268-35-0
• Molecular Formula: C₅₃H₅₅BrFNO₇Si
• Molecular Weight: 945.01

Synonyms:dibenzyl [3-(3-(allyloxy)-4-{(2S,3R)-1-^(4-)-3-[(3S)-3-{[tert-butyl(dimethyI)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}phenyl)prop-2-yn-1-yl]malonate

Chemical Property of dibenzyl [3-(3-(allyloxy)-4-{(2S,3R)-1-^(4-)-3-[(3S)-3-{[tert-butyl(dimethyI)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}phenyl)prop-2-yn-1-yl]malonate

Chemical Property:

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Technology Process of dibenzyl [3-(3-(allyloxy)-4-{(2S,3R)-1-^(4-)-3-[(3S)-3-{[tert-butyl(dimethyI)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}phenyl)prop-2-yn-1-yl]malonate

There total 1 articles about dibenzyl [3-(3-(allyloxy)-4-{(2S,3R)-1-^(4-)-3-[(3S)-3-{[tert-butyl(dimethyI)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}phenyl)prop-2-yn-1-yl]malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R,4S)-4-[2-(allyloxy)-4-iodophenyl]-1-(4-bromophenyl)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]azetidin-2-one (1227268-34-9) + 2-prop-2-ynylmalonic acid dibenzyl ester (479400-43-6) → dibenzyl [3-(3-(allyloxy)-4-{(2S,3R)-1-(4-)-3-[(3S)-3-{[tert-butyl(dimethyI)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}phenyl)prop-2-yn-1-yl]malonate (1227268-35-0)

Guidance literature:

With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere; Sealed tube;

Reference yield:

6-(methylsulfonyl)-hex-1-yne (79797-12-9) + dibenzyl [3-(3-(allyloxy)-4-{(2S,3R)-1-(4-)-3-[(3S)-3-{[tert-butyl(dimethyI)silyl]oxy}-3-(4-fluorophenyl)propyl]-4-oxoazetidin-2-yl}phenyl)prop-2-yn-1-yl]malonate (1227268-35-0) → dibenzyl {3-[4-((2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-1-{4-[6-(methylsulfonyl)hex-1-yn-1-yl]phenyl}-4-oxoazetidin-2-yl)-3-hydroxyphenyl]prop-2-yn-1-yl}malonate (1227268-36-1)

Guidance literature:

With copper(l) iodide; tetra-(n-butyl)ammonium iodide; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 70 ℃; for 10.5h; Inert atmosphere; Sealed tube;

upstream raw materials:

(3R,4S)-4-[2-(allyloxy)-4-iodophenyl]-1-(4-bromophenyl)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]azetidin-2-one

2-prop-2-ynylmalonic acid dibenzyl ester

Downstream raw materials:

dibenzyl {3-[4-((2S,3R)-3-[(3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-3-(4-fluorophenyl)propyl]-1-{4-[6-(methylsulfonyl)hex-1-yn-1-yl]phenyl}-4-oxoazetidin-2-yl)-3-hydroxyphenyl]prop-2-yn-1-yl}malonate

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