6-O-benzyl-5'-deoxy-5'-N-(N-tert-butoxycarbonyl-O-benzyloxycarbonyl)hydroxylaminoguanosine

Base Information

Chemical Name:6-O-benzyl-5'-deoxy-5'-N-(N-tert-butoxycarbonyl-O-benzyloxycarbonyl)hydroxylaminoguanosine
CAS No.:253779-53-2
Molecular Formula:C₃₀H₃₄N₆O₉
Molecular Weight:622.635
Hs Code.:

Synonyms:6-O-benzyl-5'-deoxy-5'-N-(N-tert-butoxycarbonyl-O-benzyloxycarbonyl)hydroxylaminoguanosine

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Chemical Property of 6-O-benzyl-5'-deoxy-5'-N-(N-tert-butoxycarbonyl-O-benzyloxycarbonyl)hydroxylaminoguanosine

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Technology Process of 6-O-benzyl-5'-deoxy-5'-N-(N-tert-butoxycarbonyl-O-benzyloxycarbonyl)hydroxylaminoguanosine

There total 4 articles about 6-O-benzyl-5'-deoxy-5'-N-(N-tert-butoxycarbonyl-O-benzyloxycarbonyl)hydroxylaminoguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 4552-61-8
2-amino-6-benzyloxy-9-β-D-ribofuranosylpurine

: N-(tert-butoxycarbonyl)-O-(benzyloxycarbonyl)hydroxylamine

: 253779-53-2
6-O-benzyl-5'-deoxy-5'-N-(N-tert-butoxycarbonyl-O-benzyloxycarbonyl)hydroxylaminoguanosine

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jo991153b

Reference yield:

: 72409-24-6
2',3',5'-tri-O-(tert-butyldimethylsilyl)guanosine

: 253779-53-2
6-O-benzyl-5'-deoxy-5'-N-(N-tert-butoxycarbonyl-O-benzyloxycarbonyl)hydroxylaminoguanosine

Guidance literature:: Multi-step reaction with 3 steps

1: 2.1 g / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 4 h / 20 °C

2: 92 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

3: 91 percent / triphenylphosphine; di-tert-butyl azodicarboxylate / dimethylformamide; tetrahydrofuran / 0 - 20 °C

With di-tert-butyl-diazodicarboxylate; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Alkylation / 2: desilylation / 3: Alkylation;
DOI:10.1021/jo991153b

Reference yield:

: 118-00-3
G

: 253779-53-2
6-O-benzyl-5'-deoxy-5'-N-(N-tert-butoxycarbonyl-O-benzyloxycarbonyl)hydroxylaminoguanosine

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 20 °C

2: 2.1 g / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 4 h / 20 °C

3: 92 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C

4: 91 percent / triphenylphosphine; di-tert-butyl azodicarboxylate / dimethylformamide; tetrahydrofuran / 0 - 20 °C

With 1H-imidazole; di-tert-butyl-diazodicarboxylate; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: silylation / 2: Alkylation / 3: desilylation / 4: Alkylation;
DOI:10.1021/jo991153b