Technology Process of 4-(2,6-dimethylphenyl)-5-oxo-6-phenyl-4,5-dihydropyrazine-2-carbaldehyde
There total 7 articles about 4-(2,6-dimethylphenyl)-5-oxo-6-phenyl-4,5-dihydropyrazine-2-carbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
oxygen; copper diacetate; potassium carbonate;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 2h;
under 760.051 Torr;
DOI:10.1055/s-0030-1261185
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 0 - 20 °C
2: sodium tetrahydroborate / ethanol; dichloromethane / 20 °C / Cooling with ice
3: triethylamine / dichloromethane / 1 h / Cooling with ice
4: sodium azide / N,N-dimethyl-formamide / 20 °C / Cooling with ice
5: oxygen; copper diacetate; potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / 760.05 Torr
With
sodium tetrahydroborate; sodium azide; oxygen; copper diacetate; potassium carbonate; triethylamine;
In
ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0030-1261185
- Guidance literature:
-
Multi-step reaction with 7 steps
1: water; sodium hydroxide / dichloromethane
2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C
3: triethylamine / dichloromethane / 0 - 20 °C
4: sodium tetrahydroborate / ethanol; dichloromethane / 20 °C / Cooling with ice
5: triethylamine / dichloromethane / 1 h / Cooling with ice
6: sodium azide / N,N-dimethyl-formamide / 20 °C / Cooling with ice
7: oxygen; copper diacetate; potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / 760.05 Torr
With
sodium tetrahydroborate; sodium azide; oxalyl dichloride; water; oxygen; copper diacetate; potassium carbonate; triethylamine; N,N-dimethyl-formamide; sodium hydroxide;
In
ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0030-1261185
