3-(2-amino-1-methyl-ethyl)-5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:3-(2-amino-1-methyl-ethyl)-5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester
CAS No.:292600-36-3
Molecular Formula:C₃₄H₄₆N₄O₃
Molecular Weight:558.764
Hs Code.:

3-(2-amino-1-methyl-ethyl)-5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-pyrrolo[2,3-<i>c</i>]pyridine-1-carboxylic acid <i>tert</i>-butyl ester

Synonyms:3-(2-amino-1-methyl-ethyl)-5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester

Suppliers and Price of 3-(2-amino-1-methyl-ethyl)-5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(2-amino-1-methyl-ethyl)-5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(2-amino-1-methyl-ethyl)-5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester

There total 16 articles about 3-(2-amino-1-methyl-ethyl)-5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 292600-35-2
5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-3-(2-azido-1-methyl-ethyl)-2-(3,5-dimethyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester

: 292600-36-3
3-(2-amino-1-methyl-ethyl)-5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium dihydroxide; In ethanol; at 20 ℃; for 1.5h; under 2585.74 Torr;
DOI:10.1016/S0040-4039(01)01322-3

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 292600-36-3
3-(2-amino-1-methyl-ethyl)-5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / DMAP; K₂CO₃ / CH₂Cl₂ / 1 h / 20 °C

2: 84 percent / H₂ / Pd(OH)2/C / ethanol; acetic acid / 48 h / 20 °C / 2585.74 Torr

3: Zn(N₃)2*2Py; PPh₃; imidazole / DEAD / CH₂Cl₂ / 15 h / 20 °C

4: H₂ / Pd(OH)2/C / ethanol / 1.5 h / 20 °C / 2585.74 Torr

With 1H-imidazole; dmap; zinc azide * 2 pyridine; hydrogen; potassium carbonate; triphenylphosphine; palladium dihydroxide; diethylazodicarboxylate; In ethanol; dichloromethane; acetic acid;
DOI:10.1016/S0040-4039(01)01322-3

Reference yield:

: 5845-15-8
2-azabicyclo-[2.2.2.]octane hydrochloride

: 292600-36-3
3-(2-amino-1-methyl-ethyl)-5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: PyBOP; NEt₃ / CH₂Cl₂ / 15 h / 20 °C

2: 69 percent / t-BuLi; I₂ / tetrahydrofuran / -78 - -10 °C

3: 78 percent / H₂SO₄ / H₂O / 3.5 h / 95 °C

4: 62 percent / LiCl; Na₂CO₃ / Pd(dppf)Cl₂*CH₂Cl₂ / dimethylformamide / 15 h / 100 °C

5: 98 percent / IPy₂BF₄; TfOH / CH₂Cl₂ / 1.5 h / 20 °C

6: 100 percent / Na₂CO₃ / Pd(dppf)Cl₂*CH₂Cl₂ / ethanol; toluene / 15 h / 90 °C

7: 89 percent / DMAP; K₂CO₃ / CH₂Cl₂ / 1 h / 20 °C

8: 84 percent / H₂ / Pd(OH)2/C / ethanol; acetic acid / 48 h / 20 °C / 2585.74 Torr

9: Zn(N₃)2*2Py; PPh₃; imidazole / DEAD / CH₂Cl₂ / 15 h / 20 °C

10: H₂ / Pd(OH)2/C / ethanol / 1.5 h / 20 °C / 2585.74 Torr

With 1H-imidazole; dmap; zinc azide * 2 pyridine; Barluenga reagent; trifluorormethanesulfonic acid; sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; iodine; tert.-butyl lithium; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; lithium chloride; palladium dihydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene; 6: Suzuki-Miayura cross-coupling;
DOI:10.1016/S0040-4039(01)01322-3