(R,Z)-N-((2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidin-4-yl)methylene)aniline oxide

Base Information

Chemical Name:(R,Z)-N-((2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidin-4-yl)methylene)aniline oxide
CAS No.:1352790-96-5
Molecular Formula:C₂₇H₃₈N₂O₄S
Molecular Weight:486.676
Hs Code.:

Synonyms:(R,Z)-N-((2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidin-4-yl)methylene)aniline oxide

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Chemical Property of (R,Z)-N-((2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidin-4-yl)methylene)aniline oxide

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Technology Process of (R,Z)-N-((2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidin-4-yl)methylene)aniline oxide

There total 6 articles about (R,Z)-N-((2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidin-4-yl)methylene)aniline oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1352790-95-4
(S)-2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidine-4-carbaldehyde

: 100-65-2
N-Phenylhydroxylamine

: 1352790-96-5
(R,Z)-N-((2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidin-4-yl)methylene)aniline oxide

Guidance literature:: (S)-2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidine-4-carbaldehyde; With magnesium sulfate; In dichloromethane; at 20 - 25 ℃; for 0.0833333h;

N-Phenylhydroxylamine; In dichloromethane; at 20 - 25 ℃; for 1h;
DOI:10.1002/anie.201105412

Reference yield:

: 159155-12-1
(S)-methyl 3-hydroxy-2-(2,4,6-triisopropylphenylsulfonamido)propanoate

: 1352790-96-5
(R,Z)-N-((2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidin-4-yl)methylene)aniline oxide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium p-toluenesulfonate / toluene / 16 h / 80 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

3.1: oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

4.1: magnesium sulfate / dichloromethane / 0.08 h / 20 - 25 °C

4.2: 1 h / 20 - 25 °C

With lithium aluminium tetrahydride; oxalyl dichloride; pyridinium p-toluenesulfonate; magnesium sulfate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/anie.201105412

Reference yield:

: 1352790-93-2
(S)-methyl 2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidine-4-carboxylate

: 1352790-96-5
(R,Z)-N-((2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidin-4-yl)methylene)aniline oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.1: oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C

3.1: magnesium sulfate / dichloromethane / 0.08 h / 20 - 25 °C

3.2: 1 h / 20 - 25 °C

With lithium aluminium tetrahydride; oxalyl dichloride; magnesium sulfate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.201105412