8-((4-chlorophenyl)thio)-6-(4-fluorophenyl)-2,7-naphthyridin-1(2H)-one

Base Information

Chemical Name:8-((4-chlorophenyl)thio)-6-(4-fluorophenyl)-2,7-naphthyridin-1(2H)-one
CAS No.:1428522-87-5
Molecular Formula:C₂₀H₁₂ClFN₂OS
Molecular Weight:382.845
Hs Code.:

Synonyms:8-((4-chlorophenyl)thio)-6-(4-fluorophenyl)-2,7-naphthyridin-1(2H)-one

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Chemical Property of 8-((4-chlorophenyl)thio)-6-(4-fluorophenyl)-2,7-naphthyridin-1(2H)-one

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Technology Process of 8-((4-chlorophenyl)thio)-6-(4-fluorophenyl)-2,7-naphthyridin-1(2H)-one

There total 5 articles about 8-((4-chlorophenyl)thio)-6-(4-fluorophenyl)-2,7-naphthyridin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: C₂₂H₁₇ClFN₃S

: 1428522-87-5
8-((4-chlorophenyl)thio)-6-(4-fluorophenyl)-2,7-naphthyridin-1(2H)-one

Guidance literature:: With sulfuric acid; at 70 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.02.016

Reference yield:

: 2-hydroxy-4-methyl-6-oxo-1,6-dihydropyridine-3-carbonitrile

: 1428522-87-5
8-((4-chlorophenyl)thio)-6-(4-fluorophenyl)-2,7-naphthyridin-1(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / 10 h / 90 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 3.5 h / 100 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

4: N,N-dimethyl-formamide / 3 h / 130 °C

5: sulfuric acid / 4 h / 70 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; trichlorophosphate; In 1,4-dioxane; water; N,N-dimethyl-formamide; 2: |Suzuki Coupling;
DOI:10.1016/j.tetlet.2013.02.016

Reference yield:

: 875-35-4
2,6-dichloro-4-methylnicotinonitrile

: 1428522-87-5
8-((4-chlorophenyl)thio)-6-(4-fluorophenyl)-2,7-naphthyridin-1(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 3.5 h / 100 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C / Inert atmosphere

3: N,N-dimethyl-formamide / 3 h / 130 °C

4: sulfuric acid / 4 h / 70 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling;
DOI:10.1016/j.tetlet.2013.02.016