N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-trifluoromethylbenzenesulfonamide

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Chemical Name:N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-trifluoromethylbenzenesulfonamide
CAS No.:1616689-55-4
Molecular Formula:C₂₅H₂₂F₃N₃O₃S
Molecular Weight:501.529
Hs Code.:

Synonyms:N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-trifluoromethylbenzenesulfonamide

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Chemical Property of N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-trifluoromethylbenzenesulfonamide

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Technology Process of N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-trifluoromethylbenzenesulfonamide

There total 5 articles about N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-trifluoromethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 777-44-6
3-(Trifluoromethyl)benzenesulfonyl chloride

: 1616689-81-6
1-{5-[2-(5-amino-2-methylphenyl)-ethyl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-ethanone

: 1616689-55-4
N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-trifluoromethylbenzenesulfonamide

Guidance literature:: With trimethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 1616689-80-5
1-{5-[2-(2-methyl-5-nitrophenyl)-vinyl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-ethanone

: 1616689-55-4
N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-trifluoromethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide / 7500.75 Torr

2: trimethylamine / N,N-dimethyl-formamide / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; trimethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 1616689-94-1
2-acetyl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile

: 1616689-55-4
N-{3-[2-(2-acetyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-ethyl]-4-methylphenyl}-3-trifluoromethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: diisobutylaluminium hydride / toluene / 1.5 h / 0 °C

2: manganese(IV) oxide / tetrahydrofuran / 20 °C

3: lithium hydroxide / methanol / 20 °C

4: hydrogen; palladium 10% on activated carbon / N,N-dimethyl-formamide / 7500.75 Torr

5: trimethylamine / N,N-dimethyl-formamide / 0 - 20 °C

With manganese(IV) oxide; palladium 10% on activated carbon; hydrogen; diisobutylaluminium hydride; lithium hydroxide; trimethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;