diethyl N-<4-(2-amino-5,6-dihydro-4(3H)-5-oxofuro<2,3-d>pyrimidin-5-yl)benzoyl>-L-glutamate

Base Information

Chemical Name:diethyl N-<4-(2-amino-5,6-dihydro-4(3H)-5-oxofuro<2,3-d>pyrimidin-5-yl)benzoyl>-L-glutamate
CAS No.:222295-37-6
Molecular Formula:C₂₂H₂₆N₄O₇
Molecular Weight:458.471
Hs Code.:

Synonyms:diethyl N-<4-(2-amino-5,6-dihydro-4(3H)-5-oxofuro<2,3-d>pyrimidin-5-yl)benzoyl>-L-glutamate

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Chemical Property of diethyl N-<4-(2-amino-5,6-dihydro-4(3H)-5-oxofuro<2,3-d>pyrimidin-5-yl)benzoyl>-L-glutamate

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Technology Process of diethyl N-<4-(2-amino-5,6-dihydro-4(3H)-5-oxofuro<2,3-d>pyrimidin-5-yl)benzoyl>-L-glutamate

There total 5 articles about diethyl N-<4-(2-amino-5,6-dihydro-4(3H)-5-oxofuro<2,3-d>pyrimidin-5-yl)benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 222295-35-4
diethyl N-<4-(2-amino-4(3H)-5-oxofuro<2,3-d>pyrimidin-5-yl)benzoyl>-L-glutamate

: 222295-37-6
diethyl N-<4-(2-amino-5,6-dihydro-4(3H)-5-oxofuro<2,3-d>pyrimidin-5-yl)benzoyl>-L-glutamate

Guidance literature:: With hydrogen; palladium on activated charcoal; In 1,4-dioxane; for 16h; under 760 Torr; Ambient temperature;
DOI:10.1248/cpb.47.156

Reference yield:

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 222295-37-6
diethyl N-<4-(2-amino-5,6-dihydro-4(3H)-5-oxofuro<2,3-d>pyrimidin-5-yl)benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 4-chloro-4,6-dimethoxytriazine, NMM, 2.) 4-chloro-4,6-dimethoxytrizine, NMM / 1.) DMF, RT, 2.5 h, 2.) DMF, RT, 16 h

2: 88 percent / H₂ / 5 percent Pd/C / dioxane / 16 h / 760 Torr / Ambient temperature

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; 4-chloro-4,6-dimethoxytriazine; hydrogen; palladium on activated charcoal; In 1,4-dioxane;
DOI:10.1248/cpb.47.156

Reference yield:

: methyl Z-4-(2-chloro-2-nitroethenyl)benzoate

: 222295-37-6
diethyl N-<4-(2-amino-5,6-dihydro-4(3H)-5-oxofuro<2,3-d>pyrimidin-5-yl)benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / DBU / ethanol; butan-2-one / 3 h / Heating

2: 73 percent / aq. NaOH / 3 h / Ambient temperature

3: 1.) 4-chloro-4,6-dimethoxytriazine, NMM, 2.) 4-chloro-4,6-dimethoxytrizine, NMM / 1.) DMF, RT, 2.5 h, 2.) DMF, RT, 16 h

4: 88 percent / H₂ / 5 percent Pd/C / dioxane / 16 h / 760 Torr / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; 4-chloro-4,6-dimethoxytriazine; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In 1,4-dioxane; ethanol; butanone;
DOI:10.1248/cpb.47.156