(S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-(methylsulfonyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

Base Information

Chemical Name:(S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-(methylsulfonyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide
CAS No.:1601483-67-3
Molecular Formula:C₁₈H₂₂N₄O₄S
Molecular Weight:390.463
Hs Code.:

Synonyms:(S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-(methylsulfonyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

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Chemical Property of (S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-(methylsulfonyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

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Technology Process of (S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-(methylsulfonyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

There total 11 articles about (S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-(methylsulfonyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 625-05-8
3-amino-3-methylbutanoic acid

: 1601483-67-3
(S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-(methylsulfonyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1: chloro-trimethyl-silane / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile; tetrahydrofuran / 20 h / 0 - 20 °C

3: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

4: potassium tert-butylate / toluene / 3 h / -10 - 20 °C

5: N,N-dimethyl acetamide / 1 h / 80 °C

6: potassium acetate / N,N-dimethyl-formamide / 2 h / 90 °C

7: sodium hydroxide / water; 1,4-dioxane / 3 h / 110 °C

8: oxone||potassium monopersulfate triple salt / N,N-dimethyl-formamide / 20 °C

9: trimethylsilyl iodide / acetonitrile / 1 h / 0 °C

10: N-ethyl-N,N-diisopropylamine / toluene; dichloromethane / 0.08 h / 0 °C

11: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With chloro-trimethyl-silane; trimethylsilyl iodide; oxone||potassium monopersulfate triple salt; potassium tert-butylate; potassium acetate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1584149-17-6
C₁₀H₁₂ClN₃O₃S

: 20989-17-7
(2S)-2-phenylglycinol

: 1601483-67-3
(S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-(methylsulfonyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1584148-41-3
methyl 3-(((benzyloxy)carbonyl)(2-methoxy-2-oxoethyl)amino)-3-methylbutanoate

: 1601483-67-3
(S)-N-(2-hydroxy-1-phenylethyl)-5,5-dimethyl-2-(methylsulfonyl)-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: potassium tert-butylate / toluene / 3 h / -10 - 20 °C

2: N,N-dimethyl acetamide / 1 h / 80 °C

3: potassium acetate / N,N-dimethyl-formamide / 2 h / 90 °C

4: sodium hydroxide / water; 1,4-dioxane / 3 h / 110 °C

5: oxone||potassium monopersulfate triple salt / N,N-dimethyl-formamide / 20 °C

6: trimethylsilyl iodide / acetonitrile / 1 h / 0 °C

7: N-ethyl-N,N-diisopropylamine / toluene; dichloromethane / 0.08 h / 0 °C

8: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With trimethylsilyl iodide; oxone||potassium monopersulfate triple salt; potassium tert-butylate; potassium acetate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; toluene; acetonitrile;