4-chloro-1-(2-C-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-d]pyridazine

Base Information

• Chemical Name: 4-chloro-1-(2-C-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-d]pyridazine
• CAS No.: 832743-29-0
• Molecular Formula: C₃₂H₂₅ClN₄O₇
• Molecular Weight: 613.026

Synonyms:4-chloro-1-(2-C-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-d]pyridazine

Chemical Property of 4-chloro-1-(2-C-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-d]pyridazine

Chemical Property:

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Technology Process of 4-chloro-1-(2-C-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-d]pyridazine

There total 3 articles about 4-chloro-1-(2-C-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-d]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(2-C-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-d]pyridazin-4-one (832743-28-9) → 4-chloro-1-(2-C-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-d]pyridazine (832743-29-0)

Guidance literature:

With N,N-diethylaniline; trichlorophosphate; for 4h; Heating;

DOI:10.1081/NCN-200060225

Reference yield:

(1H)-Imidazo<4,5-d>pyriddazine-4(5H)-one (28682-94-2) → 4-chloro-1-(2-C-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-d]pyridazine (832743-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 16 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene; trimethylsilyl triflate / acetonitrile / 20 h / 80 °C

2: 95 percent / POCl₃; N,N-diethylaniline / 4 h / Heating

With trimethylsilyl trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-diethylaniline; trichlorophosphate; In acetonitrile;

DOI:10.1081/NCN-200060225

Reference yield:

(2S/R,3R,4R,5R)-5-((benzoyloxy)methyl)-3-methyltetrahydrofuran-2,3,4-triyltribenzoate → 4-chloro-1-(2-C-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-d]pyridazine (832743-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 16 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene; trimethylsilyl triflate / acetonitrile / 20 h / 80 °C

2: 95 percent / POCl₃; N,N-diethylaniline / 4 h / Heating

With trimethylsilyl trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-diethylaniline; trichlorophosphate; In acetonitrile;

DOI:10.1081/NCN-200060225

upstream raw materials:

1-(2-C-methyl-2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo[4,5-d]pyridazin-4-one

(1H)-Imidazo<4,5-d>pyriddazine-4(5H)-one

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