(R)-3-Hydroxy-2-[(4'-propyl-biphenyl-4-carbonyl)-amino]-propionic acid methyl ester

Base Information

• Chemical Name: (R)-3-Hydroxy-2-[(4'-propyl-biphenyl-4-carbonyl)-amino]-propionic acid methyl ester
• CAS No.: 1027426-91-0
• Molecular Formula: C₂₀H₂₃NO₄
• Molecular Weight: 341.407
• Mol file: 1027426-91-0.mol

Synonyms:(R)-3-Hydroxy-2-[(4'-propyl-biphenyl-4-carbonyl)-amino]-propionic acid methyl ester

Chemical Property of (R)-3-Hydroxy-2-[(4'-propyl-biphenyl-4-carbonyl)-amino]-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (R)-3-Hydroxy-2-[(4'-propyl-biphenyl-4-carbonyl)-amino]-propionic acid methyl ester

There total 1 articles about (R)-3-Hydroxy-2-[(4'-propyl-biphenyl-4-carbonyl)-amino]-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

R-(-)-serine methyl ester hydrochloride (5874-57-7) + 4-(4-n-propylphenyl)benzoic acid (88038-94-2) → (R)-3-Hydroxy-2-[(4'-propyl-biphenyl-4-carbonyl)-amino]-propionic acid methyl ester (1027426-91-0)

Guidance literature:

With AtH₂⁽¹⁺⁾*HO^(1-); N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1021/jm010579r

Reference yield:

(R)-3-Hydroxy-2-[(4'-propyl-biphenyl-4-carbonyl)-amino]-propionic acid methyl ester (1027426-91-0) → (R)-2-(4'-Propyl-biphenyl-4-yl)-4,5-dihydro-oxazole-4-carboxylic acid methyl ester (1027281-62-4)

Guidance literature:

With 4,4'-diaminostilbene-2,2'-disulfonic acid; In dichloromethane; at -7 ℃; for 1h;

DOI:10.1021/jm010579r

upstream raw materials:

R-(-)-serine methyl ester hydrochloride

4-(4-n-propylphenyl)benzoic acid

Downstream raw materials:

(R)-2-(4'-Propyl-biphenyl-4-yl)-4,5-dihydro-oxazole-4-carboxylic acid methyl ester