N-allyl-N-(4-(2-(dimethylamino)phenyl)but-3-yn-2-yl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-allyl-N-(4-(2-(dimethylamino)phenyl)but-3-yn-2-yl)-4-methylbenzenesulfonamide
• CAS No.: 1443647-15-1
• Molecular Formula: C₂₂H₂₆N₂O₂S
• Molecular Weight: 382.527
• Mol file: 1443647-15-1.mol

Synonyms:N-allyl-N-(4-(2-(dimethylamino)phenyl)but-3-yn-2-yl)-4-methylbenzenesulfonamide

Chemical Property of N-allyl-N-(4-(2-(dimethylamino)phenyl)but-3-yn-2-yl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

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Technology Process of N-allyl-N-(4-(2-(dimethylamino)phenyl)but-3-yn-2-yl)-4-methylbenzenesulfonamide

There total 1 articles about N-allyl-N-(4-(2-(dimethylamino)phenyl)but-3-yn-2-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

N,N-dimethyl-o-iodoaniline (698-02-2) + N-(1-Methylprop-2-ynyl)-N-(2-propenyl)-4-methylbenzenesulfonamide (132330-52-0) → N-allyl-N-(4-(2-(dimethylamino)phenyl)but-3-yn-2-yl)-4-methylbenzenesulfonamide (1443647-15-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol401303f

Reference yield: 59.0%

N-allyl-N-(4-(2-(dimethylamino)phenyl)but-3-yn-2-yl)-4-methylbenzenesulfonamide (1443647-15-1) → (1S,4S)/(1R,4R)-4-(iodomethyl)-1,9-dimethyl-2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole + (1S,4R)/(1R,4S)-4-(iodomethyl)-1,9-dimethyl-2-tosyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

Guidance literature:

With iodine; In 1,2-dichloro-ethane; at 70 ℃; for 3h; Overall yield = 93 %;

DOI:10.1021/ol401303f

upstream raw materials:

N,N-dimethyl-o-iodoaniline

N-(1-Methylprop-2-ynyl)-N-(2-propenyl)-4-methylbenzenesulfonamide