(Z)-3-[1-(1-phenylethylamino)ethylidene]tetrahydro-2-furanone

Base Information

• Chemical Name: (Z)-3-[1-(1-phenylethylamino)ethylidene]tetrahydro-2-furanone
• CAS No.: 1007224-95-4
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231.294
• Mol file: 1007224-95-4.mol

Synonyms:(Z)-3-[1-(1-phenylethylamino)ethylidene]tetrahydro-2-furanone

Chemical Property of (Z)-3-[1-(1-phenylethylamino)ethylidene]tetrahydro-2-furanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-3-[1-(1-phenylethylamino)ethylidene]tetrahydro-2-furanone

There total 1 articles about (Z)-3-[1-(1-phenylethylamino)ethylidene]tetrahydro-2-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-acetyl-2-oxo-4,5-dihydrofuran (517-23-7,594837-91-9,98634-97-0,313643-49-1) + (S)-1-phenyl-ethylamine (2627-86-3) → (Z)-3-[1-(1-phenylethylamino)ethylidene]tetrahydro-2-furanone (1007224-95-4)

Guidance literature:

for 4h; Ambient temperature;

DOI:10.1016/0957-4166(94)80112-6

Reference yield: 41.0%

1-(3,4-dimethoxybenzyloxy)-3-buten-2-one (1007224-92-1) + (Z)-3-[1-(1-phenylethylamino)ethylidene]tetrahydro-2-furanone (1007224-95-4) → 8-(3,4-dimethoxybenzyloxymethyl)-2-oxaspiro[4.5]dec-7-ene-1,6-dione

Guidance literature:

1-(3,4-dimethoxybenzyloxy)-3-buten-2-one; (Z)-3-[1-(1-phenylethylamino)ethylidene]tetrahydro-2-furanone; In tetrahydrofuran; at 65 ℃;

With acetic acid; In tetrahydrofuran; at 20 ℃; Further stages.;

DOI:10.1002/ejoc.200700691

Reference yield:

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + (Z)-3-[1-(1-phenylethylamino)ethylidene]tetrahydro-2-furanone (1007224-95-4) → 3-((R)-2-Oxo-3-{1-[(E)-(S)-1-phenyl-ethylimino]-ethyl}-tetrahydro-furan-3-yl)-propionic acid methyl ester (158530-91-7) + 3-((S)-2-Oxo-3-{1-[(E)-(S)-1-phenyl-ethylimino]-ethyl}-tetrahydro-furan-3-yl)-propionic acid methyl ester

Guidance literature:

at 80 ℃; for 12h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/0957-4166(94)80112-6

upstream raw materials:

3-acetyl-2-oxo-4,5-dihydrofuran

(S)-1-phenyl-ethylamine

Downstream raw materials:

3-((R)-2-Oxo-3-{1-[(E)-(S)-1-phenyl-ethylimino]-ethyl}-tetrahydro-furan-3-yl)-propionic acid methyl ester