Technology Process of methyl 8-benzoyl-(2S,3S,6R,8R)-nonactate
There total 19 articles about methyl 8-benzoyl-(2S,3S,6R,8R)-nonactate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 95 percent / iodine, triphenylphosphine, imidazole / diethyl ether; acetonitrile / 10.5 h / Ambient temperature
2: 1.) NaH, n-BuLi / 1.) THF, HMPA, hexane, 25 min, 2.) THF, HMPA, hexane, 10 min
3: boric acid, H2 / Ra-Ni / methanol; H2O / 21 h
4: oxalic acid / CH2Cl2 / 2 h / Heating
5: 95 percent / L-selectride / tetrahydrofuran / 0.17 h / -78 °C
6: 62 percent / H2 / 5percent Rh/Al2O3 / methanol / 120 h / 3620.04 Torr
7: 92 percent / triphenylphosphine, DEAD / tetrahydrofuran / 17 h
With
1H-imidazole; n-butyllithium; hydrogen; iodine; boric acid; oxalic acid; L-Selectride; sodium hydride; triphenylphosphine; diethylazodicarboxylate;
Rh/Al2O3; Ra-Ni;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1016/0040-4020(95)00913-2
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 91 percent / L-selectride / tetrahydrofuran / 0.33 h / Ambient temperature
2: 95 percent / iodine, triphenylphosphine, imidazole / diethyl ether; acetonitrile / 10.5 h / Ambient temperature
3: 1.) NaH, n-BuLi / 1.) THF, HMPA, hexane, 25 min, 2.) THF, HMPA, hexane, 10 min
4: boric acid, H2 / Ra-Ni / methanol; H2O / 21 h
5: oxalic acid / CH2Cl2 / 2 h / Heating
6: 95 percent / L-selectride / tetrahydrofuran / 0.17 h / -78 °C
7: 62 percent / H2 / 5percent Rh/Al2O3 / methanol / 120 h / 3620.04 Torr
8: 92 percent / triphenylphosphine, DEAD / tetrahydrofuran / 17 h
With
1H-imidazole; n-butyllithium; hydrogen; iodine; boric acid; oxalic acid; L-Selectride; sodium hydride; triphenylphosphine; diethylazodicarboxylate;
Rh/Al2O3; Ra-Ni;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1016/0040-4020(95)00913-2
