(1-benzyl-2-hex-1-ynyl-2-hydroxy-oct-3-ynyl)carbamic acid tert-butyl ester

Base Information

• Chemical Name: (1-benzyl-2-hex-1-ynyl-2-hydroxy-oct-3-ynyl)carbamic acid tert-butyl ester
• CAS No.: 1371568-31-8
• Molecular Formula: C₂₆H₃₇NO₃
• Molecular Weight: 411.585
• Mol file: 1371568-31-8.mol

Synonyms:(1-benzyl-2-hex-1-ynyl-2-hydroxy-oct-3-ynyl)carbamic acid tert-butyl ester

Chemical Property of (1-benzyl-2-hex-1-ynyl-2-hydroxy-oct-3-ynyl)carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-benzyl-2-hex-1-ynyl-2-hydroxy-oct-3-ynyl)carbamic acid tert-butyl ester

There total 2 articles about (1-benzyl-2-hex-1-ynyl-2-hydroxy-oct-3-ynyl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

methyl 2-tert-butoxycarbonylamino-3-phenylpropanoate (51987-73-6,77119-84-7,19901-50-9) + hex-1-yne (693-02-7) → (1-benzyl-2-hex-1-ynyl-2-hydroxy-oct-3-ynyl)carbamic acid tert-butyl ester (1371568-31-8)

Guidance literature:

hex-1-yne; With ethyl bromide; magnesium; In tetrahydrofuran; at 0 - 45 ℃; for 2.25h; Inert atmosphere;

methyl 2-tert-butoxycarbonylamino-3-phenylpropanoate; In tetrahydrofuran; at 35 ℃; Inert atmosphere;

DOI:10.1021/jo300365n

Reference yield: 35.0%

hexenylmagnesium bromide (32359-01-6) + methyl 2-tert-butoxycarbonylamino-3-phenylpropanoate (51987-73-6,77119-84-7,19901-50-9) → (1-benzyl-2-hex-1-ynyl-2-hydroxy-oct-3-ynyl)carbamic acid tert-butyl ester (1371568-31-8)

Guidance literature:

In tetrahydrofuran; at 25 - 35 ℃; Inert atmosphere;

DOI:10.1002/chem.201203800

Reference yield: 95.0%

(1-benzyl-2-hex-1-ynyl-2-hydroxy-oct-3-ynyl)carbamic acid tert-butyl ester (1371568-31-8) → 2-benzyl-5-butyl-3-hex-1-ynyl-pyrrole-1-carboxylic acid tert-butyl ester (1429939-15-0)

Guidance literature:

With gold(III) chloride; at 50 ℃; for 0.25h; Reagent/catalyst; Time; Temperature; Microwave irradiation;

DOI:10.1002/chem.201203800

upstream raw materials:

methyl 2-tert-butoxycarbonylamino-3-phenylpropanoate

hex-1-yne

hexenylmagnesium bromide

Downstream raw materials:

methyl 5-benzyl-2-butyl-4-hexanoyl-1H-pyrrole-3-carboxylate

C₂₆H₃₄INO₂

C₂₆H₃₄I₃NO₂

2-benzyl-5-butyl-3-hex-1-ynyl-pyrrole-1-carboxylic acid tert-butyl ester