methyl 2-(3-benzyloxycarbonyl-2-tert-butoxycarbonylaminopropanoyl)amino-3-oxobutanoate

Base Information

Chemical Name:methyl 2-(3-benzyloxycarbonyl-2-tert-butoxycarbonylaminopropanoyl)amino-3-oxobutanoate
CAS No.:706785-46-8
Molecular Formula:C₂₁H₂₈N₂O₈
Molecular Weight:436.462
Hs Code.:

Synonyms:methyl 2-(3-benzyloxycarbonyl-2-tert-butoxycarbonylaminopropanoyl)amino-3-oxobutanoate

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Chemical Property of methyl 2-(3-benzyloxycarbonyl-2-tert-butoxycarbonylaminopropanoyl)amino-3-oxobutanoate

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Technology Process of methyl 2-(3-benzyloxycarbonyl-2-tert-butoxycarbonylaminopropanoyl)amino-3-oxobutanoate

There total 3 articles about methyl 2-(3-benzyloxycarbonyl-2-tert-butoxycarbonylaminopropanoyl)amino-3-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 24762-04-7
2-Diazo-3-oxo-butyric acid methyl ester

: 87421-27-0
N-t-butyloxycarbonyl-L-aspartic acid β-benzyl ester α-amide

: 706785-46-8
methyl 2-(3-benzyloxycarbonyl-2-tert-butoxycarbonylaminopropanoyl)amino-3-oxobutanoate

Guidance literature:: With rhodium (II) octanoate dimer; In dichloromethane; Heating;
DOI:10.1039/b401580k

Reference yield:

: 7536-58-5,98482-77-0
BOC-L-aspartic acid 4-benzyl ester

: 706785-46-8
methyl 2-(3-benzyloxycarbonyl-2-tert-butoxycarbonylaminopropanoyl)amino-3-oxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; ethyl chloroformate / tetrahydrofuran / 0.5 h / 0 °C

1.2: 96 percent / aq. NH₃ / tetrahydrofuran / 1 h / 0 °C

2.1: 74 percent / dirhodium tetraoctanoate / CH₂Cl₂ / 9 h / Heating

With rhodium (II) octanoate dimer; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja0547937

Reference yield:

: (S)-3-tert-Butoxycarbonylamino-4-ethoxycarbonyloxy-4-oxo-butyric acid benzyl ester

: 706785-46-8
methyl 2-(3-benzyloxycarbonyl-2-tert-butoxycarbonylaminopropanoyl)amino-3-oxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NH₃ / tetrahydrofuran

2: 74 percent / Rh₂(octanoate)4 / CH₂Cl₂ / Heating

With ammonium hydroxide; rhodium (II) octanoate dimer; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b401580k