5'-O-(t-butyldimethylsilyl)-3'-C-((4,4'-dimethoxytrityl)oxymethyl)thymidine

Base Information

Chemical Name:5'-O-(t-butyldimethylsilyl)-3'-C-((4,4'-dimethoxytrityl)oxymethyl)thymidine
CAS No.:170638-72-9
Molecular Formula:C₃₈H₄₈N₂O₈Si
Molecular Weight:688.893
Hs Code.:

Synonyms:5'-O-(t-butyldimethylsilyl)-3'-C-((4,4'-dimethoxytrityl)oxymethyl)thymidine

Suppliers and Price of 5'-O-(t-butyldimethylsilyl)-3'-C-((4,4'-dimethoxytrityl)oxymethyl)thymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-(t-butyldimethylsilyl)-3'-C-((4,4'-dimethoxytrityl)oxymethyl)thymidine

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Technology Process of 5'-O-(t-butyldimethylsilyl)-3'-C-((4,4'-dimethoxytrityl)oxymethyl)thymidine

There total 3 articles about 5'-O-(t-butyldimethylsilyl)-3'-C-((4,4'-dimethoxytrityl)oxymethyl)thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 170638-71-8
5'-O-(tert-butyldimethylsilyl)-3'-C-hydroxymethylthymidine

: 170638-72-9
5'-O-(t-butyldimethylsilyl)-3'-C-((4,4'-dimethoxytrityl)oxymethyl)thymidine

Guidance literature:: In pyridine;
DOI:10.1080/15257779508012502

Reference yield:

: 40733-28-6
5'-tert-butyldimethylsilyloxy-2'-deoxythymidine

: 170638-72-9
5'-O-(t-butyldimethylsilyl)-3'-C-((4,4'-dimethoxytrityl)oxymethyl)thymidine

Guidance literature:: Multi-step reaction with 4 steps

1: 62 percent / PDC / CH₂Cl₂ / 4 h / Ambient temperature

2: 99 percent / Zn dust, TiCl₄ / CH₂Cl₂; tetrahydrofuran / 2 h / Ambient temperature

3: 43 percent / OsO₄, N-methylmorpholine-N-oxide, H₂O, pyridine / 2-methyl-propan-2-ol / 6 h / 76 °C

4: 47 percent / pyridine / 24 h / Ambient temperature

With pyridine; osmium(VIII) oxide; dipyridinium dichromate; water; titanium tetrachloride; 4-methylmorpholine N-oxide; zinc; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;
DOI:10.1080/15257779508009485

Reference yield:

: 170638-74-1
1-[(2R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-methylene-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

: 170638-72-9
5'-O-(t-butyldimethylsilyl)-3'-C-((4,4'-dimethoxytrityl)oxymethyl)thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / OsO₄, N-methylmorpholine-N-oxide, H₂O, pyridine / 2-methyl-propan-2-ol / 6 h / 76 °C

2: 47 percent / pyridine / 24 h / Ambient temperature

With pyridine; osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; In tert-butyl alcohol;
DOI:10.1080/15257779508009485