ethyl 7-[(2R)-2-{(1E,3S)-3-hydroxy-4-(3-fluorophenyl)-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]heptanoate

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Chemical Name:ethyl 7-[(2R)-2-{(1E,3S)-3-hydroxy-4-(3-fluorophenyl)-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]heptanoate
CAS No.:1365391-94-1
Molecular Formula:C₂₃H₃₂FNO₄
Molecular Weight:405.51
Hs Code.:

Synonyms:ethyl 7-[(2R)-2-{(1E,3S)-3-hydroxy-4-(3-fluorophenyl)-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]heptanoate

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Chemical Property of ethyl 7-[(2R)-2-{(1E,3S)-3-hydroxy-4-(3-fluorophenyl)-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]heptanoate

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Technology Process of ethyl 7-[(2R)-2-{(1E,3S)-3-hydroxy-4-(3-fluorophenyl)-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]heptanoate

There total 6 articles about ethyl 7-[(2R)-2-{(1E,3S)-3-hydroxy-4-(3-fluorophenyl)-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₃₀FNO₄

: 1365391-94-1
ethyl 7-[(2R)-2-{(1E,3S)-3-hydroxy-4-(3-fluorophenyl)-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]heptanoate

Guidance literature:: With borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at 20 ℃; for 1.08333h; stereoselective reaction; Inert atmosphere;
DOI:10.1248/cpb.59.1523

Reference yield:

: 946402-22-8
N-methoxy-N-methyl-2-(3-fluorophenyl)acetamide

: 1365391-94-1
ethyl 7-[(2R)-2-{(1E,3S)-3-hydroxy-4-(3-fluorophenyl)-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]heptanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; toluene / 1 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 0 °C / Inert atmosphere

3.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 1.08 h / 20 °C / Inert atmosphere

With n-butyllithium; borane-THF; sodium hydride; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; hexane; toluene; mineral oil; 2.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1248/cpb.59.1523

Reference yield:

: 431989-86-5
dimethyl [3-(3-fluorophenyl)-2-oxopropane]phosphonate

: 1365391-94-1
ethyl 7-[(2R)-2-{(1E,3S)-3-hydroxy-4-(3-fluorophenyl)-1-buten-1-yl}-5-oxo-1-pyrrolidinyl]heptanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 1.5 h / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 0 °C / Inert atmosphere

2.1: borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 1.08 h / 20 °C / Inert atmosphere

With borane-THF; sodium hydride; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; mineral oil; 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1248/cpb.59.1523