4-(2-(2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)thiazol-4-yl)benzonitrile

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Chemical Name:4-(2-(2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)thiazol-4-yl)benzonitrile
CAS No.:1416805-29-2
Molecular Formula:C₂₀H₁₂F₄N₆OS
Molecular Weight:460.414
Hs Code.:

Synonyms:4-(2-(2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)thiazol-4-yl)benzonitrile

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Chemical Property of 4-(2-(2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)thiazol-4-yl)benzonitrile

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Technology Process of 4-(2-(2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)thiazol-4-yl)benzonitrile

There total 4 articles about 4-(2-(2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)thiazol-4-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 288-94-8
1H-tetrazole

: 1416805-90-7
C₁₉H₁₀F₄N₂OS

: 1416805-29-2
4-(2-(2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)thiazol-4-yl)benzonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 16h; Inert atmosphere;

Reference yield:

: 311797-30-5
ethyl 2-(4-bromo-2-thiazolyl)-2,2-difluoroacetate

: 1416805-29-2
4-(2-(2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)thiazol-4-yl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C

1.2: 2 h / -70 - 20 °C

2.1: diethyl ether / 0 - 20 °C

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 16 h / 55 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

With n-butyllithium; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; diethyl ether; hexane; water; N,N-dimethyl-formamide;

Reference yield:

: 294182-15-3
2-(4-bromo-2-thiazolyl)-2,2-difluoro-1-(2,4-difluorophenyl)ethanone

: 1416805-29-2
4-(2-(2-(2,4-Difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1H-tetrazol-1-yl)propyl)thiazol-4-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / 0 - 20 °C

2: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 16 h / 55 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide;