(R)-α-deuteriobenzyl alcohol (R)-α-methoxy-α-(trifluormethyl)phenylacetate

Base Information

Chemical Name:(R)-α-deuteriobenzyl alcohol (R)-α-methoxy-α-(trifluormethyl)phenylacetate
CAS No.:127847-98-7
Molecular Formula:C₁₇H₁₅F₃O₃
Molecular Weight:325.292
Hs Code.:

Synonyms:(R)-α-deuteriobenzyl alcohol (R)-α-methoxy-α-(trifluormethyl)phenylacetate

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Chemical Property of (R)-α-deuteriobenzyl alcohol (R)-α-methoxy-α-(trifluormethyl)phenylacetate

Chemical Property:

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Technology Process of (R)-α-deuteriobenzyl alcohol (R)-α-methoxy-α-(trifluormethyl)phenylacetate

There total 11 articles about (R)-α-deuteriobenzyl alcohol (R)-α-methoxy-α-(trifluormethyl)phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 4181-90-2
(R)-(α-2H)benzyl alcohol

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 127847-98-7
(R)-α-deuteriobenzyl alcohol (R)-α-methoxy-α-(trifluormethyl)phenylacetate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1002/ejoc.201300439

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 127847-98-7
(R)-α-deuteriobenzyl alcohol (R)-α-methoxy-α-(trifluormethyl)phenylacetate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 18 h / 80 °C / Inert atmosphere

2: pyridine / dichloromethane / 18 h / 20 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; 1: |Stille Cross Coupling;
DOI:10.1002/ejoc.201300439

Reference yield:

: dimethylphenyl((S)-phenyl[D₁]methyl)silane

: 127847-97-6,127847-98-7,127986-94-1
(S)-α-deuteriobenzyl alcohol (R)-α-methoxy-α-(trifluormethyl)phenylacetate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrafluoroboric acid diethyl ether / dichloromethane / 2 h / 0 - 20 °C

2: potassium fluoride; sodium hydrogencarbonate; dihydrogen peroxide / tetrahydrofuran; methanol / 2 h / Reflux

3: pyridine / dichloromethane / 18 h / 20 °C / Inert atmosphere

With pyridine; tetrafluoroboric acid diethyl ether; potassium fluoride; dihydrogen peroxide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; dichloromethane; 2: |Tamao-Kumada Oxidation;
DOI:10.1002/ejoc.201300439