Trifluopromazine hydrochloride

Base Information

• Chemical Name: Trifluopromazine hydrochloride
• CAS No.: 1098-60-8
• Molecular Formula: C18H19 F3 N2 S . Cl H
• Molecular Weight: 388.884
• Hs Code.: 2934302300
• Mol file: 1098-60-8.mol

Synonyms:Trifluopromazine hydrochloride;Fluopromazine monohydrochloride;CHEBI:9712;AKOS026749861

Chemical Property of Trifluopromazine hydrochloride

Chemical Property:

• Appearance/Colour: Crystals
• Vapor Pressure: 1.62E-07mmHg at 25°C
• Melting Point: 174.0 to 179.0 °C
• Boiling Point: 427.6 °C at 760 mmHg
• Flash Point: 212.4 °C
• PSA: 31.78000
• LogP: 6.12680
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 388.0987820
• Heavy Atom Count: 25
• Complexity: 416

Purity/Quality:

98%,99%, ^*data from raw suppliers

Triflupromazine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: [H+].CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)C(F)(F)F.[Cl-]
• Description: Triflupromazine is a phenothiazine with diverse biological activities. It binds to muscarinic receptors in isolated rat corpus striatum (IC50 = 100 μM in a radioligand binding assay). Triflupromazine inhibits serotonin (5-HT) uptake by isolated rat brainstem synaptosomes (IC50 = 0.8 μM). It inhibits T. cruzi infection in mouse peritoneal macrophages when used at a concentration of 12.5 μM. Triflupromazine is active against S. aureus, shigellae, and vibrios (MICs = 2-100 μg/ml) in vitro and is protective against S. typhimurium infection in mice when administered at a dose of 30 μg per animal. Formulations containing triflupromazine were previously used as antipsychotics.
• Uses: analgesic, antiinflammatory, antipyretic, COX-II inhibitor
• Therapeutic Function: Tranquilizer

Technology Process of Trifluopromazine hydrochloride

There total 1 articles about Trifluopromazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ triflupromazine hydrochloride (1098-60-8)

Guidance literature:

aus 10-Cyanoethyl-verb., H2/Ra-Ni, HCO2H, CH2O;