N'-(3-fluoro-4-{[6-methoxy-7-({1-[(methylamino)-2-oxoethyl]piperidin-4-yl}oxy)quinolin-4-yl]oxy}phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Base Information

Chemical Name:N'-(3-fluoro-4-{[6-methoxy-7-({1-[(methylamino)-2-oxoethyl]piperidin-4-yl}oxy)quinolin-4-yl]oxy}phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
CAS No.:1416320-80-3
Molecular Formula:C₃₅H₃₅F₂N₅O₆
Molecular Weight:659.69
Hs Code.:

N'-(3-fluoro-4-{[6-methoxy-7-({1-[(methylamino)-2-oxoethyl]piperidin-4-yl}oxy)quinolin-4-yl]oxy}phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Synonyms:N'-(3-fluoro-4-{[6-methoxy-7-({1-[(methylamino)-2-oxoethyl]piperidin-4-yl}oxy)quinolin-4-yl]oxy}phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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Chemical Property of N'-(3-fluoro-4-{[6-methoxy-7-({1-[(methylamino)-2-oxoethyl]piperidin-4-yl}oxy)quinolin-4-yl]oxy}phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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Technology Process of N'-(3-fluoro-4-{[6-methoxy-7-({1-[(methylamino)-2-oxoethyl]piperidin-4-yl}oxy)quinolin-4-yl]oxy}phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

There total 9 articles about N'-(3-fluoro-4-{[6-methoxy-7-({1-[(methylamino)-2-oxoethyl]piperidin-4-yl}oxy)quinolin-4-yl]oxy}phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carbonyl chloride

: 2-(4-((4-(2-fluoro-4-aminophenoxy)-6-methoxyquinolin-7-yl)oxy)piperidin-1-yl)-N-methylacetamide

: 1416320-80-3
N'-(3-fluoro-4-{[6-methoxy-7-({1-[(methylamino)-2-oxoethyl]piperidin-4-yl}oxy)quinolin-4-yl]oxy}phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: tert-butyl 4-((4-(2-fluoro-4-nitrophenoxy)-6-methoxyquinolin-7-yl)oxy)piperidine-1-carboxylate

: 1416320-80-3
N'-(3-fluoro-4-{[6-methoxy-7-({1-[(methylamino)-2-oxoethyl]piperidin-4-yl}oxy)quinolin-4-yl]oxy}phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: potassium carbonate / acetonitrile / 3 h / Reflux

3: iron; ammonium chloride / ethanol; water / 1 h / Inert atmosphere; Reflux

4: tetrahydrofuran / 3 h / 20 °C

With iron; potassium carbonate; ammonium chloride; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-(piperidin-4-yloxy)quinoline

: 1416320-80-3
N'-(3-fluoro-4-{[6-methoxy-7-({1-[(methylamino)-2-oxoethyl]piperidin-4-yl}oxy)quinolin-4-yl]oxy}phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 3 h / Reflux

2: iron; ammonium chloride / ethanol; water / 1 h / Inert atmosphere; Reflux

3: tetrahydrofuran / 3 h / 20 °C

With iron; potassium carbonate; ammonium chloride; In tetrahydrofuran; ethanol; water; acetonitrile;