(2R,4S,6S)-2-{[(2S,4S,6S)-4-(tert-butyldiphenylsilyl)oxy-6-(iodomethyl)tetrahydro-2H-pyran-2-yl]methyl}-6-(iodomethyl)tetrahydro-2H-pyran-4-ol

Base Information

Chemical Name:(2R,4S,6S)-2-{[(2S,4S,6S)-4-(tert-butyldiphenylsilyl)oxy-6-(iodomethyl)tetrahydro-2H-pyran-2-yl]methyl}-6-(iodomethyl)tetrahydro-2H-pyran-4-ol
CAS No.:1613144-98-1
Molecular Formula:C₂₉H₄₀I₂O₄Si
Molecular Weight:734.529
Hs Code.:

Synonyms:(2R,4S,6S)-2-{[(2S,4S,6S)-4-(tert-butyldiphenylsilyl)oxy-6-(iodomethyl)tetrahydro-2H-pyran-2-yl]methyl}-6-(iodomethyl)tetrahydro-2H-pyran-4-ol

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Chemical Property of (2R,4S,6S)-2-{[(2S,4S,6S)-4-(tert-butyldiphenylsilyl)oxy-6-(iodomethyl)tetrahydro-2H-pyran-2-yl]methyl}-6-(iodomethyl)tetrahydro-2H-pyran-4-ol

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Technology Process of (2R,4S,6S)-2-{[(2S,4S,6S)-4-(tert-butyldiphenylsilyl)oxy-6-(iodomethyl)tetrahydro-2H-pyran-2-yl]methyl}-6-(iodomethyl)tetrahydro-2H-pyran-4-ol

There total 2 articles about (2R,4S,6S)-2-{[(2S,4S,6S)-4-(tert-butyldiphenylsilyl)oxy-6-(iodomethyl)tetrahydro-2H-pyran-2-yl]methyl}-6-(iodomethyl)tetrahydro-2H-pyran-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1613144-88-9
{(2S,4S,6S)-4-[(tert-butyldiphenylsilyl)oxy]-6-[((2R,4S,6S)-4-hydroxy-6-(tosyloxymethyl)tetrahydro-2H-pyran-2-yl)methyl]tetrahydro-2H-pyran-2-yl}methyl 4-methylbenzenesulfonate

: 1613144-98-1
(2R,4S,6S)-2-{[(2S,4S,6S)-4-(tert-butyldiphenylsilyl)oxy-6-(iodomethyl)tetrahydro-2H-pyran-2-yl]methyl}-6-(iodomethyl)tetrahydro-2H-pyran-4-ol

Guidance literature:: With sodium iodide; In acetone; at 120 ℃; for 2h; Inert atmosphere; Microwave irradiation; Sealed tube;
DOI:10.1039/c4cc02702g

Reference yield:

: 118629-75-7
(S)-2-hydroxypent-4-en-1-yl 4-methylbenzenesulfonate

: 1613144-98-1
(2R,4S,6S)-2-{[(2S,4S,6S)-4-(tert-butyldiphenylsilyl)oxy-6-(iodomethyl)tetrahydro-2H-pyran-2-yl]methyl}-6-(iodomethyl)tetrahydro-2H-pyran-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / pH > 7 / Inert atmosphere

2.1: sodium iodide / acetone / 2 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed tube

With trifluoroacetic acid; sodium iodide; In dichloromethane; acetone;
DOI:10.1039/c4cc02702g

Reference yield: 77.0%

: 1613144-98-1
(2R,4S,6S)-2-{[(2S,4S,6S)-4-(tert-butyldiphenylsilyl)oxy-6-(iodomethyl)tetrahydro-2H-pyran-2-yl]methyl}-6-(iodomethyl)tetrahydro-2H-pyran-4-ol

: 1613145-10-0
(4R,6R,8S,10R)-10-[(tert-butyldiphenylsilyl)oxy]trideca-1,12-diene-4,6,8-triol

Guidance literature:: With ammonium chloride; zinc; In ethanol; diastereoselective reaction; Inert atmosphere; Sealed tube; Heating;
DOI:10.1039/c4cc02702g