2-diphenylphosphanyl-N-(ethoxycarbonylmethyl)terephthalamic acid methyl ester

Base Information

• Chemical Name: 2-diphenylphosphanyl-N-(ethoxycarbonylmethyl)terephthalamic acid methyl ester
• CAS No.: 628708-16-7
• Molecular Formula: C₂₅H₂₄NO₅P
• Molecular Weight: 449.443

Synonyms:2-diphenylphosphanyl-N-(ethoxycarbonylmethyl)terephthalamic acid methyl ester

Chemical Property of 2-diphenylphosphanyl-N-(ethoxycarbonylmethyl)terephthalamic acid methyl ester

Chemical Property:

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Technology Process of 2-diphenylphosphanyl-N-(ethoxycarbonylmethyl)terephthalamic acid methyl ester

There total 2 articles about 2-diphenylphosphanyl-N-(ethoxycarbonylmethyl)terephthalamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glycine ethyl ester hydrochloride (623-33-6) + 2-(diphenylphosphanyl)terephthalic acid 1-methyl ester 4-(N-succinimidyl) ester (532931-48-9) → 2-diphenylphosphanyl-N-(ethoxycarbonylmethyl)terephthalamic acid methyl ester (628708-16-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1021/ol035635s

Reference yield:

3-(diphenylphosphino)-4-(methoxycarbonyl)benzoic acid (361154-31-6) → 2-diphenylphosphanyl-N-(ethoxycarbonylmethyl)terephthalamic acid methyl ester (628708-16-7)

Guidance literature:

Multi-step reaction with 2 steps

1: diisopropylethylamine / tetrahydrofuran; dimethylformamide; H₂O / 1 h / 20 °C

2: 79.4 mg / diisopropylethylamine / tetrahydrofuran; dimethylformamide; H₂O / 4 h / 20 °C

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;

DOI:10.1021/ol035635s

Reference yield: 84.0%

8-azidoadenosine (4372-67-2,15830-80-5) + 2-diphenylphosphanyl-N-(ethoxycarbonylmethyl)terephthalamic acid methyl ester (628708-16-7) → [4-{[(Z)-6-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-8-ylimino]-methoxy-methyl}-3-(diphenyl-phosphinoyl)-benzoylamino]-acetic acid ethyl ester

Guidance literature:

In tetrahydrofuran; water; at 30 ℃; for 2h;

DOI:10.1021/ol035635s

upstream raw materials:

glycine ethyl ester hydrochloride

2-(diphenylphosphanyl)terephthalic acid 1-methyl ester 4-(N-succinimidyl) ester

3-(diphenylphosphino)-4-(methoxycarbonyl)benzoic acid

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