FUCOSTEROL

Base Information

• Chemical Name: FUCOSTEROL
• CAS No.: 17605-67-3
• Molecular Formula: C₂₉H₄₈O
• Molecular Weight: 412.7
• Mol file: 17605-67-3.mol

Synonyms:Fucosterol(6CI);Stigmasta-5,24(28)-dien-3b-ol, (E)- (8CI);(28E)-24-Ethylcholesta-5,24(28)-dien-3-ol;(E)-Stigmasta-5,24-(28)-dien-3b-ol;24-Ethylcholesta-5,24(28)E-dien-3b-ol;24E-Ethylidenecholest-5-en-3b-ol;Fucosterin;Stigmasta-5,trans-24(28)-dien-3b-ol;trans-24-Ethylidenecholesterol;trans-Stigmasta-5,24(28)-dien-3b-ol;

Chemical Property of FUCOSTEROL

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 2.8E-12mmHg at 25°C
• Melting Point: 118-120°C
• Refractive Index: 1.53
• Boiling Point: 504.2 °C at 760 mmHg
• PKA: 15.03±0.70(Predicted)
• Flash Point: 220.3 °C
• PSA: 20.23000
• Density: 0.98 g/cm³
• LogP: 7.94490
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Fucosterol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fucosterol is a steroid for proteomics research.

Technology Process of FUCOSTEROL

There total 16 articles about FUCOSTEROL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

fucosterol acetate (51297-12-2) → 28-Isofucosterol (481-14-1,6793-19-7,17605-67-3,18472-36-1,83997-22-2,109062-46-6)

Guidance literature:

With potassium carbonate; In methanol;

DOI:10.1002/cber.19701030902

Reference yield:

C34(13)CH62OSi → 28-Isofucosterol (481-14-1,6793-19-7,17605-67-3,18472-36-1,83997-22-2,109062-46-6) + C28(13)CH48O + C28(13)CH48O + C28(13)CH48O

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 2.5h; Title compound not separated from byproducts;

DOI:10.1016/S0031-9422(00)00122-9

Reference yield:

24-oxocholesterol (17752-16-8) → 28-Isofucosterol (481-14-1,6793-19-7,17605-67-3,18472-36-1,83997-22-2,109062-46-6)

Guidance literature:

Multi-step reaction with 2 steps

2: aq. K₂CO₃ / methanol

With potassium carbonate; In methanol;

DOI:10.1002/cber.19701030902

upstream raw materials:

3β-acetoxy-24ξH-stigmast-5-en-24-ol

fucosterol acetate

24-methylene cholesterol

S-Adenosyl-L-methionine

Downstream raw materials:

Stigmastanol

3.5-dinitro-benzoic acid-(5α-stigmastanyl-(3β)-ester)

(24R)-5α-stigmastan-3β-ol benzoate

stigmastan-3-one

Refernces

• 1、 Nes, W. David,McCourt, Brian S.,Marshall, Julie A.,Ma, Jianzhong,Dennis, Allen L.,Lopez, Monica,Li, Haoxia,He, Ling. "Site-directed mutagenesis of the sterol methyl transferase active site from Saccharomyces cerevisiae results in formation of novel 24-ethyl sterols". . p. 1535 - 1542. Retrieved 2007/10/03.
• 2、 Sucrow,Radüchel. "The synthesis of (24(28)e)-stigmasta-5, 24(28)-die-3 beta-ol and (24(28)e)-alpha-stigmasta-7,24(28)-dien-3 beta-ol". . p. 2711 - 2717. Retrieved 2007/10/19.