C₁₈H₁₈FNO

Base Information

Chemical Name:C₁₈H₁₈FNO
CAS No.:1318251-48-7
Molecular Formula:C₁₈H₁₈FNO
Molecular Weight:283.345
Hs Code.:

Synonyms:C₁₈H₁₈FNO

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Chemical Property of C₁₈H₁₈FNO

Chemical Property:

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Technology Process of C₁₈H₁₈FNO

There total 8 articles about C₁₈H₁₈FNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1318251-60-3
C₂₅H₂₄FNO₄S

: 1318251-48-7
C₁₈H₁₈FNO

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium iodide; In 1,2-dimethoxyethane; at 80 ℃;
DOI:10.1016/j.tetlet.2011.05.120

Reference yield:

: 1318251-56-7
C₂₀H₂₁NO₂S

: 1318251-48-7
C₁₈H₁₈FNO

Guidance literature:: Multi-step reaction with 5 steps

1: isopropyl alcohol / 80 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / ethanol / Reflux

3: bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate / 1,2-dimethoxyethane; water

4: pyridine / dichloromethane

5: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium iodide / 1,2-dimethoxyethane / 80 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydrogencarbonate; isopropyl alcohol; sodium iodide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 3: Suzuki coupling;
DOI:10.1016/j.tetlet.2011.05.120

Reference yield:

: thiophene-3-carboxylic acid (2-bromo-phenyl)-methyl-amide

: 1318251-48-7
C₁₈H₁₈FNO

Guidance literature:: Multi-step reaction with 7 steps

1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 110 °C

2: toluene-4-sulfonic acid / toluene / 20 °C

3: isopropyl alcohol / 80 °C

4: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / ethanol / Reflux

5: bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate / 1,2-dimethoxyethane; water

6: pyridine / dichloromethane

7: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium iodide / 1,2-dimethoxyethane / 80 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; isopropyl alcohol; sodium iodide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; toluene; 5: Suzuki coupling;
DOI:10.1016/j.tetlet.2011.05.120