4-(1-diazo-2-oxo-2-phenylethyl)-2-ethoxy-4-hydroxy-2-methyl-2-cyclobutenone

Base Information

• Chemical Name: 4-(1-diazo-2-oxo-2-phenylethyl)-2-ethoxy-4-hydroxy-2-methyl-2-cyclobutenone
• CAS No.: 220841-51-0
• Molecular Formula: C₁₅H₁₄N₂O₄
• Molecular Weight: 286.287
• Mol file: 220841-51-0.mol

Synonyms:4-(1-diazo-2-oxo-2-phenylethyl)-2-ethoxy-4-hydroxy-2-methyl-2-cyclobutenone

Chemical Property of 4-(1-diazo-2-oxo-2-phenylethyl)-2-ethoxy-4-hydroxy-2-methyl-2-cyclobutenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(1-diazo-2-oxo-2-phenylethyl)-2-ethoxy-4-hydroxy-2-methyl-2-cyclobutenone

There total 1 articles about 4-(1-diazo-2-oxo-2-phenylethyl)-2-ethoxy-4-hydroxy-2-methyl-2-cyclobutenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

2-diazo-acetophenone (3282-32-4) + 3-ethoxy-4-methyl-3-cyclobutene-1,2-dione (75966-09-5) → 4-(1-diazo-2-oxo-2-phenylethyl)-2-ethoxy-4-hydroxy-2-methyl-2-cyclobutenone (220841-51-0)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1021/jo980523d

Reference yield: 83.0%

4-(1-diazo-2-oxo-2-phenylethyl)-2-ethoxy-4-hydroxy-2-methyl-2-cyclobutenone (220841-51-0) → 2-benzoyl-4-ethoxy-5-methyl-4-cyclopentene-1,3-dione

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1021/jo980523d

Reference yield: 24.0%

4-(1-diazo-2-oxo-2-phenylethyl)-2-ethoxy-4-hydroxy-2-methyl-2-cyclobutenone (220841-51-0) → 2-benzoyl-4-ethoxy-5-methyl-4-cyclopentene-1,3-dione + 3-benzoyl-5-ethoxy-6-methyl-1,2(1H)-diazepine-4,7-dione

Guidance literature:

In xylene; for 2h; Heating;

DOI:10.1021/jo980523d

upstream raw materials:

2-diazo-acetophenone

3-ethoxy-4-methyl-3-cyclobutene-1,2-dione