3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-acetyl-docetaxel

Base Information

Chemical Name:3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-acetyl-docetaxel
CAS No.:926306-84-5
Molecular Formula:C₄₁H₅₀ClF₂NO₁₅
Molecular Weight:870.296
Hs Code.:

Synonyms:3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-acetyl-docetaxel

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-acetyl-docetaxel

Chemical Property:

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Technology Process of 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-acetyl-docetaxel

There total 9 articles about 3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-acetyl-docetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₆H₈₄ClF₂NO₁₅Si₂

: 926306-84-5
3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-acetyl-docetaxel

Guidance literature:: With pyridine; hydrogen fluoride; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: C₃₅H₄₉ClO₁₀Si

: 926306-84-5
3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-acetyl-docetaxel

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran

2: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C

3: pyridine; hydrogen fluoride / acetonitrile / 0 - 20 °C

With pyridine; hydrogen fluoride; lithium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: 926306-99-2
(3R,4S)-1-(4-methoxyphenyl)-3-triisopropylsiloxy-4-(2,2-difluorovinyl)azetidin-2-one

: 926306-84-5
3'-dephenyl-3'-(2,2-difluoroethenyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-acetyl-docetaxel

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium cerium (IV) nitrate; water / acetonitrile / 2 h / -10 °C

2: triethylamine; dmap / dichloromethane / 18 h / 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C

4: pyridine; hydrogen fluoride / acetonitrile / 0 - 20 °C

With pyridine; dmap; ammonium cerium (IV) nitrate; hydrogen fluoride; water; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007