trifluoromethanesulfonic acid N-(p-methoxybenzyl)-2-oxoazepan-4-yl ester

Base Information

Chemical Name:trifluoromethanesulfonic acid N-(p-methoxybenzyl)-2-oxoazepan-4-yl ester
CAS No.:910248-52-1
Molecular Formula:C₁₅H₁₆F₃NO₅S
Molecular Weight:379.357
Hs Code.:

Synonyms:trifluoromethanesulfonic acid N-(p-methoxybenzyl)-2-oxoazepan-4-yl ester

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Chemical Property of trifluoromethanesulfonic acid N-(p-methoxybenzyl)-2-oxoazepan-4-yl ester

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Technology Process of trifluoromethanesulfonic acid N-(p-methoxybenzyl)-2-oxoazepan-4-yl ester

There total 6 articles about trifluoromethanesulfonic acid N-(p-methoxybenzyl)-2-oxoazepan-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 910248-54-3
N-(p-methoxybenzyl)azepane-2,4-dione

: 358-23-6
trifluoromethylsulfonic anhydride

: 910248-52-1
trifluoromethanesulfonic acid N-(p-methoxybenzyl)-2-oxoazepan-4-yl ester

Guidance literature:: With sodium hydroxide; In dichloromethane; at 0 - 20 ℃; for 12h;
DOI:10.1055/s-2006-942441

Reference yield:

: 910248-53-2
4-ethoxy-N-(p-methoxybenzyl)-1,5,6,7-tetrahydroazepin-2-one

: 910248-52-1
trifluoromethanesulfonic acid N-(p-methoxybenzyl)-2-oxoazepan-4-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / aq. HCl / ethanol / 50 °C

2: 60 percent / aq. NaOH / CH₂Cl₂ / 12 h / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1055/s-2006-942441

Reference yield:

: 5323-87-5
3-Ethoxycyclohex-2-en-1-one

: 910248-52-1
trifluoromethanesulfonic acid N-(p-methoxybenzyl)-2-oxoazepan-4-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 43 percent / NH₂OH*HCl; NaOAc / ethanol / 12 h / 55 - 60 °C

2: 80 percent / p-TsCl; Et₃N / tetrahydrofuran / 1 h / 0 - 5 °C

3: 63 percent / NaH / dimethylformamide / 6 h / 20 °C

4: 87 percent / aq. HCl / ethanol / 50 °C

5: 60 percent / aq. NaOH / CH₂Cl₂ / 12 h / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; hydroxylamine hydrochloride; sodium acetate; sodium hydride; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 2: Beckmann rearrangement;
DOI:10.1055/s-2006-942441