5-<<4-<2-<(4-nitrocyclohexyl)amino>-2-oxoethyl>phenyl>amino>-5-oxopentanoic acid

Base Information

• Chemical Name: 5-<<4-<2-<(4-nitrocyclohexyl)amino>-2-oxoethyl>phenyl>amino>-5-oxopentanoic acid
• CAS No.: 130468-91-6
• Molecular Formula: C₁₉H₂₅N₃O₆
• Molecular Weight: 391.424
• Mol file: 130468-91-6.mol

Synonyms:5-<<4-<2-<(4-nitrocyclohexyl)amino>-2-oxoethyl>phenyl>amino>-5-oxopentanoic acid

Chemical Property of 5-<<4-<2-<(4-nitrocyclohexyl)amino>-2-oxoethyl>phenyl>amino>-5-oxopentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-<<4-<2-<(4-nitrocyclohexyl)amino>-2-oxoethyl>phenyl>amino>-5-oxopentanoic acid

There total 6 articles about 5-<<4-<2-<(4-nitrocyclohexyl)amino>-2-oxoethyl>phenyl>amino>-5-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

glutaric anhydride, (108-55-4) + N-(4-nitrocyclohexyl)-4-aminobenzeneacetamide (130468-94-9) → 5-<<4-<2-<(4-nitrocyclohexyl)amino>-2-oxoethyl>phenyl>amino>-5-oxopentanoic acid (130468-91-6)

Guidance literature:

With triethylamine; In acetonitrile; at 57 ℃; for 4h;

DOI:10.1021/ja00001a042

Reference yield:

4-aminophenylacetic acid (1197-55-3) → 5-<<4-<2-<(4-nitrocyclohexyl)amino>-2-oxoethyl>phenyl>amino>-5-oxopentanoic acid (130468-91-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 85 percent / sodium carbonate, water / acetonitrile / 0.17 h / 0 °C

2: 98 percent / thionyl chloride / 5 h / 55 °C

3: 68 percent / triethylamine, 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / 3 h / 45 °C

4: sodium borohydride / ethanol / 24 h / 60 °C

5: 17 percent / triethylamine / acetonitrile / 4 h / 57 °C

With dmap; sodium tetrahydroborate; thionyl chloride; water; sodium carbonate; triethylamine; In ethanol; dichloromethane; acetonitrile;

DOI:10.1021/ja00001a042

Reference yield:

4-<(trifluoroacetyl)amino>benzeneacetyl chloride (113180-63-5) → 5-<<4-<2-<(4-nitrocyclohexyl)amino>-2-oxoethyl>phenyl>amino>-5-oxopentanoic acid (130468-91-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 68 percent / triethylamine, 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂ / 3 h / 45 °C

2: sodium borohydride / ethanol / 24 h / 60 °C

3: 17 percent / triethylamine / acetonitrile / 4 h / 57 °C

With dmap; sodium tetrahydroborate; triethylamine; In ethanol; dichloromethane; acetonitrile;

DOI:10.1021/ja00001a042

upstream raw materials:

glutaric anhydride,

N-(4-nitrocyclohexyl)-4-aminobenzeneacetamide

4-aminophenylacetic acid

4-<(trifluoroacetyl)amino>benzeneacetyl chloride