(5R)-2-((R)-((4-chlorophthalazin-1-yl)oxy)(6-(trityloxy)quinolin-4-yl)methyl)-5-ethylquinuclidine

Base Information

Chemical Name:(5R)-2-((R)-((4-chlorophthalazin-1-yl)oxy)(6-(trityloxy)quinolin-4-yl)methyl)-5-ethylquinuclidine
CAS No.:1352717-63-5
Molecular Formula:C₄₆H₄₁ClN₄O₂
Molecular Weight:717.31
Hs Code.:

Synonyms:(5R)-2-((R)-((4-chlorophthalazin-1-yl)oxy)(6-(trityloxy)quinolin-4-yl)methyl)-5-ethylquinuclidine

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Chemical Property of (5R)-2-((R)-((4-chlorophthalazin-1-yl)oxy)(6-(trityloxy)quinolin-4-yl)methyl)-5-ethylquinuclidine

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Technology Process of (5R)-2-((R)-((4-chlorophthalazin-1-yl)oxy)(6-(trityloxy)quinolin-4-yl)methyl)-5-ethylquinuclidine

There total 3 articles about (5R)-2-((R)-((4-chlorophthalazin-1-yl)oxy)(6-(trityloxy)quinolin-4-yl)methyl)-5-ethylquinuclidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 4752-10-7
1,4-dichlorophthalazine

: 1236951-52-2
C₃₈H₃₈N₂O₂

: 1352717-63-5
(5R)-2-((R)-((4-chlorophthalazin-1-yl)oxy)(6-(trityloxy)quinolin-4-yl)methyl)-5-ethylquinuclidine

Guidance literature:: C₃₈H₃₈N₂O₂; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h; Inert atmosphere;

1,4-dichlorophthalazine; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.08.070

Reference yield:

: 522-66-7
dihydroquinine

: 1352717-63-5
(5R)-2-((R)-((4-chlorophthalazin-1-yl)oxy)(6-(trityloxy)quinolin-4-yl)methyl)-5-ethylquinuclidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen bromide / water / Reflux

2.1: tetrabutylammomium bromide; sodium hydroxide / water / 0.25 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

With tetrabutylammomium bromide; hydrogen bromide; sodium hydride; sodium hydroxide; In tetrahydrofuran; water; mineral oil;
DOI:10.1016/j.tet.2011.08.070

Reference yield:

: 4-[(R)-((2S,4S,5R)-5-Ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-hydroxy-methyl]-quinolin-6-ol

: 1352717-63-5
(5R)-2-((R)-((4-chlorophthalazin-1-yl)oxy)(6-(trityloxy)quinolin-4-yl)methyl)-5-ethylquinuclidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutylammomium bromide; sodium hydroxide / water / 0.25 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 20 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With tetrabutylammomium bromide; sodium hydride; sodium hydroxide; In tetrahydrofuran; water; mineral oil;
DOI:10.1016/j.tet.2011.08.070