phenylmethyl (8R)-8-methyl-5,7-dioxa-6-thia-2-azaspiro[3.4]octane-2-carboxylate 6,6-dioxide

Base Information

Chemical Name:phenylmethyl (8R)-8-methyl-5,7-dioxa-6-thia-2-azaspiro[3.4]octane-2-carboxylate 6,6-dioxide
CAS No.:1373446-67-3
Molecular Formula:C₁₃H₁₅NO₆S
Molecular Weight:313.331
Hs Code.:

Synonyms:phenylmethyl (8R)-8-methyl-5,7-dioxa-6-thia-2-azaspiro[3.4]octane-2-carboxylate 6,6-dioxide

Suppliers and Price of phenylmethyl (8R)-8-methyl-5,7-dioxa-6-thia-2-azaspiro[3.4]octane-2-carboxylate 6,6-dioxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of phenylmethyl (8R)-8-methyl-5,7-dioxa-6-thia-2-azaspiro[3.4]octane-2-carboxylate 6,6-dioxide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of phenylmethyl (8R)-8-methyl-5,7-dioxa-6-thia-2-azaspiro[3.4]octane-2-carboxylate 6,6-dioxide

There total 4 articles about phenylmethyl (8R)-8-methyl-5,7-dioxa-6-thia-2-azaspiro[3.4]octane-2-carboxylate 6,6-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1373446-60-6
phenylmethyl 3-hydroxy-3-[(1R)-1-hydroxyethyl]azetidine-1-carboxylate

: 1373446-67-3
phenylmethyl (8R)-8-methyl-5,7-dioxa-6-thia-2-azaspiro[3.4]octane-2-carboxylate 6,6-dioxide

Guidance literature:: phenylmethyl 3-hydroxy-3-[(1R)-1-hydroxyethyl]azetidine-1-carboxylate; With pyridine; thionyl chloride; In dichloromethane; at 20 ℃; for 1h; Cooling with ice; Reflux;

With sodium periodate; ruthenium(III) trichloride hydrate; In water; acetonitrile; at 20 ℃; for 2h; Cooling with ice;
DOI:10.1021/ml300049d

Reference yield:

: 1373446-66-2
1,1-dimethylethyl 3-hydroxy-3-[(1R)-1-hydroxyethyl]azetidine-1-carboxylate

: 1373446-67-3
phenylmethyl (8R)-8-methyl-5,7-dioxa-6-thia-2-azaspiro[3.4]octane-2-carboxylate 6,6-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane; methanol / 0.25 h / Reflux

2.1: sodium hydrogencarbonate / 1,4-dioxane; water / 15 h / 20 °C / Cooling with ice

3.1: pyridine; thionyl chloride / dichloromethane / 1 h / 20 °C / Cooling with ice; Reflux

3.2: 2 h / 20 °C / Cooling with ice

With pyridine; hydrogenchloride; thionyl chloride; sodium hydrogencarbonate; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1021/ml300049d

Reference yield:

: C₅H₁₁NO₂

: 1373446-67-3
phenylmethyl (8R)-8-methyl-5,7-dioxa-6-thia-2-azaspiro[3.4]octane-2-carboxylate 6,6-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane; water / 15 h / 20 °C / Cooling with ice

2.1: pyridine; thionyl chloride / dichloromethane / 1 h / 20 °C / Cooling with ice; Reflux

2.2: 2 h / 20 °C / Cooling with ice

With pyridine; thionyl chloride; sodium hydrogencarbonate; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/ml300049d