(S)-1-benzyloxy-2-<(2R,5S,6R)-6-<(S)-1-(methoxymethoxymethyl)ethyl>-5-methyltetrahydropyran-2-yl>butane

Base Information

Chemical Name:(S)-1-benzyloxy-2-<(2R,5S,6R)-6-<(S)-1-(methoxymethoxymethyl)ethyl>-5-methyltetrahydropyran-2-yl>butane
CAS No.:126365-67-1
Molecular Formula:C₂₂H₃₆O₄
Molecular Weight:364.525
Hs Code.:

Synonyms:(S)-1-benzyloxy-2-<(2R,5S,6R)-6-<(S)-1-(methoxymethoxymethyl)ethyl>-5-methyltetrahydropyran-2-yl>butane

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Chemical Property of (S)-1-benzyloxy-2-<(2R,5S,6R)-6-<(S)-1-(methoxymethoxymethyl)ethyl>-5-methyltetrahydropyran-2-yl>butane

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Technology Process of (S)-1-benzyloxy-2-<(2R,5S,6R)-6-<(S)-1-(methoxymethoxymethyl)ethyl>-5-methyltetrahydropyran-2-yl>butane

There total 5 articles about (S)-1-benzyloxy-2-<(2R,5S,6R)-6-<(S)-1-(methoxymethoxymethyl)ethyl>-5-methyltetrahydropyran-2-yl>butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126365-66-0
(R)-methyl 2-[(2R,5S,6R)-6-[(S)-1-hydroxypropan-2-yl]-5-methyltetrahydro-2H-pyran-2-yl]butanoate

: 126365-67-1
(S)-1-benzyloxy-2-<(2R,5S,6R)-6-<(S)-1-(methoxymethoxymethyl)ethyl>-5-methyltetrahydropyran-2-yl>butane

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / EtN(iPr)2 / CH₂Cl₂ / Ambient temperature

2: 94 percent / LiAlH₄ / tetrahydrofuran

3: 1) NaH / 1) DMSO, THF, RT, 2) DMSO, THF, RT, overnight

With lithium aluminium tetrahydride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.37.1726

Reference yield:

: 110410-59-8
(R)-methyl 2-[(2R,5S,6R)-5-methyl-6-[(S)-1-oxopropan-2-yl]tetrahydro-2H-pyran-2-yl]butanoate

: 126365-67-1
(S)-1-benzyloxy-2-<(2R,5S,6R)-6-<(S)-1-(methoxymethoxymethyl)ethyl>-5-methyltetrahydropyran-2-yl>butane

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / NaBH₄ / methanol / 0.25 h / 0 °C

2: 95 percent / EtN(iPr)2 / CH₂Cl₂ / Ambient temperature

3: 94 percent / LiAlH₄ / tetrahydrofuran

4: 1) NaH / 1) DMSO, THF, RT, 2) DMSO, THF, RT, overnight

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1248/cpb.37.1726

Reference yield:

: 126419-21-4
methyl (R)-2-<(2R,5S,6R)-6-<(S)-1-(methoxymethoxymethyl)ethyl>-5-methyltetrahydropyran-2-yl>butanoate

: 126365-67-1
(S)-1-benzyloxy-2-<(2R,5S,6R)-6-<(S)-1-(methoxymethoxymethyl)ethyl>-5-methyltetrahydropyran-2-yl>butane

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / LiAlH₄ / tetrahydrofuran

2: 1) NaH / 1) DMSO, THF, RT, 2) DMSO, THF, RT, overnight

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran;
DOI:10.1248/cpb.37.1726