Technology Process of 3-allyl-1-benzyl-3-fluoroazocane
There total 5 articles about 3-allyl-1-benzyl-3-fluoroazocane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diethylamino-sulfur trifluoride;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/jo300887u
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetone / 12 h / Inert atmosphere; Reflux
2.1: sodium azide; methanesulfonic acid / chloroform / 2 h / 0 °C / Inert atmosphere; Reflux
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere; Reflux
3.2: 0 °C / Inert atmosphere
4.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 4 h / Inert atmosphere; Reflux
5.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; sodium azide; methanesulfonic acid; diethylamino-sulfur trifluoride; tetra-(n-butyl)ammonium iodide; potassium carbonate;
In
tetrahydrofuran; dichloromethane; chloroform; acetone; acetonitrile;
DOI:10.1021/jo300887u
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere; Reflux
1.2: 0 °C / Inert atmosphere
2.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 4 h / Inert atmosphere; Reflux
3.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; diethylamino-sulfur trifluoride; tetra-(n-butyl)ammonium iodide; potassium carbonate;
In
tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo300887u
