cis-10b,10c-dimethyl-2t-(4-nitrobenzyl)decahydro-3a,5a,8a,10a-tetraazapyrene

Base Information

• Chemical Name: cis-10b,10c-dimethyl-2t-(4-nitrobenzyl)decahydro-3a,5a,8a,10a-tetraazapyrene
• CAS No.: 693785-41-0
• Molecular Formula: C₂₁H₃₁N₅O₂
• Molecular Weight: 385.509
• Mol file: 693785-41-0.mol

Synonyms:cis-10b,10c-dimethyl-2t-(4-nitrobenzyl)decahydro-3a,5a,8a,10a-tetraazapyrene

Chemical Property of cis-10b,10c-dimethyl-2t-(4-nitrobenzyl)decahydro-3a,5a,8a,10a-tetraazapyrene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cis-10b,10c-dimethyl-2t-(4-nitrobenzyl)decahydro-3a,5a,8a,10a-tetraazapyrene

There total 4 articles about cis-10b,10c-dimethyl-2t-(4-nitrobenzyl)decahydro-3a,5a,8a,10a-tetraazapyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

9a,9b-dimethyloctahydro-1,3a,6a,9-tetra-azaphenalene (214195-99-0) + 2-(4-nitrobenzyl)-1,3-dibromopropane (693785-40-9) → cis-10b,10c-dimethyl-2t-(4-nitrobenzyl)decahydro-3a,5a,8a,10a-tetraazapyrene (693785-41-0)

Guidance literature:

With potassium carbonate; In acetonitrile; at 60 ℃; for 120h;

DOI:10.1016/j.tetlet.2004.02.108

Reference yield:

diethyl 2-(4-nitrobenzyl)malonate (7598-70-1) → cis-10b,10c-dimethyl-2t-(4-nitrobenzyl)decahydro-3a,5a,8a,10a-tetraazapyrene (693785-41-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / BH₃*SMe₂ / tetrahydrofuran / 72 h / Heating

2: 92 percent / PBr₃; pyridine / 1 h / 90 - 100 °C

3: 74 percent / K₂CO₃ / acetonitrile / 120 h / 60 °C

With pyridine; dimethylsulfide borane complex; phosphorus tribromide; potassium carbonate; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.tetlet.2004.02.108

Reference yield:

2-[(4-nitrophenyl)methyl]propan-1,3-diol (73344-98-6) → cis-10b,10c-dimethyl-2t-(4-nitrobenzyl)decahydro-3a,5a,8a,10a-tetraazapyrene (693785-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / PBr₃; pyridine / 1 h / 90 - 100 °C

2: 74 percent / K₂CO₃ / acetonitrile / 120 h / 60 °C

With pyridine; phosphorus tribromide; potassium carbonate; In acetonitrile;

DOI:10.1016/j.tetlet.2004.02.108

upstream raw materials:

9a,9b-dimethyloctahydro-1,3a,6a,9-tetra-azaphenalene

2-(4-nitrobenzyl)-1,3-dibromopropane

diethyl 2-(4-nitrobenzyl)malonate

2-[(4-nitrophenyl)methyl]propan-1,3-diol

Downstream raw materials:

13-(4-nitrobenzyl)-1,4,8,11-tetraazacyclotetradecane