(+)-N-(5aS-hydroxymethyl-3-oxo-3aα,6aα-cyclopent[c]furan-4βR-yl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:(+)-N-(5aS-hydroxymethyl-3-oxo-3aα,6aα-cyclopent[c]furan-4βR-yl)-4-methylbenzenesulfonamide
CAS No.:175464-25-2
Molecular Formula:C₁₅H₁₉NO₅S
Molecular Weight:325.386
Hs Code.:

Synonyms:(+)-N-(5aS-hydroxymethyl-3-oxo-3aα,6aα-cyclopent[c]furan-4βR-yl)-4-methylbenzenesulfonamide

Suppliers and Price of (+)-N-(5aS-hydroxymethyl-3-oxo-3aα,6aα-cyclopent[c]furan-4βR-yl)-4-methylbenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+)-N-(5aS-hydroxymethyl-3-oxo-3aα,6aα-cyclopent[c]furan-4βR-yl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+)-N-(5aS-hydroxymethyl-3-oxo-3aα,6aα-cyclopent[c]furan-4βR-yl)-4-methylbenzenesulfonamide

There total 3 articles about (+)-N-(5aS-hydroxymethyl-3-oxo-3aα,6aα-cyclopent[c]furan-4βR-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 175464-24-1
(-)-3R-[[(4-methylphenyl)sulfonyl]amino]bicyclo[2.2.1]hept-5-ene-2αR carboxylic acid

: 175464-25-2
(+)-N-(5aS-hydroxymethyl-3-oxo-3aα,6aα-cyclopent[c]furan-4βR-yl)-4-methylbenzenesulfonamide

Guidance literature:: (-)-3R-[[(4-methylphenyl)sulfonyl]amino]bicyclo[2.2.1]hept-5-ene-2αR carboxylic acid; With ozone; In methanol; ethyl acetate; at -78 ℃;

With sodium tetrahydroborate; at -78 - 20 ℃; for 40h;

With hydrogenchloride; In methanol; at 20 ℃; for 72h;
DOI:10.1016/S0040-4020(99)00680-8

Reference yield:

: 175464-23-0
(-)-N-(3aβ,6aβ-hexahydro-6β-iodo-2-oxo-3αR,5α-methano-2H-cyclopenta[b]furan-7S-yl)-4-methylbenzenesulfonamide

: 175464-25-2
(+)-N-(5aS-hydroxymethyl-3-oxo-3aα,6aα-cyclopent[c]furan-4βR-yl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / Zn / acetic acid / 0.5 h / Heating

2.1: O₃ / ethyl acetate; methanol / -78 °C

2.2: NaBH₄ / 40 h / -78 - 20 °C

2.3: 100 percent / 2N HCl / methanol / 72 h / 20 °C

With ozone; zinc; In methanol; acetic acid; ethyl acetate; 1.1: Ring cleavage / 2.1: ozonolysis / 2.2: Reduction / 2.3: acidification;
DOI:10.1016/S0040-4020(99)00680-8

Reference yield:

: (+)-hexahydro-6β-iodo-2-oxo-3αR,5α-methano-2H-3aβ,6aβ-cyclopenta[b]furan-7S-amine 4-methylbenzenesulfonate

: 175464-25-2
(+)-N-(5aS-hydroxymethyl-3-oxo-3aα,6aα-cyclopent[c]furan-4βR-yl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / pyridine / 2 h

2.1: 97 percent / Zn / acetic acid / 0.5 h / Heating

3.1: O₃ / ethyl acetate; methanol / -78 °C

3.2: NaBH₄ / 40 h / -78 - 20 °C

3.3: 100 percent / 2N HCl / methanol / 72 h / 20 °C

With ozone; zinc; In pyridine; methanol; acetic acid; ethyl acetate; 1.1: Tosylation / 2.1: Ring cleavage / 3.1: ozonolysis / 3.2: Reduction / 3.3: acidification;
DOI:10.1016/S0040-4020(99)00680-8