5-(benzyloxy)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole

Base Information

• Chemical Name: 5-(benzyloxy)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole
• CAS No.: 1000786-73-1
• Molecular Formula: C₂₁H₂₇NO₂Si
• Molecular Weight: 353.536
• Mol file: 1000786-73-1.mol

Synonyms:5-(benzyloxy)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole

Chemical Property of 5-(benzyloxy)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(benzyloxy)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole

There total 1 articles about 5-(benzyloxy)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-benzyloxy-1H-indole (1215-59-4) + (2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → 5-(benzyloxy)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole (1000786-73-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2007.09.069

Reference yield: 88.0%

iodobenzene (591-50-4) + 5-(benzyloxy)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole (1000786-73-1) → 5-(benzyloxy)-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole

Guidance literature:

With water; palladium diacetate; silver cyclohexanecarboxylate; at 30 ℃; for 16h;

DOI:10.1002/chem.201302838

upstream raw materials:

5-benzyloxy-1H-indole

(2-trimethylethylsilylethoxy)methyl chloride