(4S)-4-Methyl-1-<(S)-1'-phenylethyl>-4-(2''-thienylmethyl)-2-imidazolin-5-on

Base Information

• Chemical Name: (4S)-4-Methyl-1-<(S)-1'-phenylethyl>-4-(2''-thienylmethyl)-2-imidazolin-5-on
• CAS No.: 65484-52-8
• Molecular Formula: C₁₇H₁₈N₂OS
• Molecular Weight: 298.409
• Mol file: 65484-52-8.mol

Synonyms:(4S)-4-Methyl-1-<(S)-1'-phenylethyl>-4-(2''-thienylmethyl)-2-imidazolin-5-on

Chemical Property of (4S)-4-Methyl-1-<(S)-1'-phenylethyl>-4-(2''-thienylmethyl)-2-imidazolin-5-on

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S)-4-Methyl-1-<(S)-1'-phenylethyl>-4-(2''-thienylmethyl)-2-imidazolin-5-on

There total 15 articles about (4S)-4-Methyl-1-<(S)-1'-phenylethyl>-4-(2''-thienylmethyl)-2-imidazolin-5-on which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-thenyl bromide (45438-73-1) + 2-Isocyan-N-<(S)-1'-phenylethyl>propionsaeureamid (65484-40-4) → (4S)-4-Methyl-1-<(S)-1'-phenylethyl>-4-(2''-thienylmethyl)-2-imidazolin-5-on (65484-52-8)

Guidance literature:

Multistep reaction; (i) nBuLi, THF, hexane, (ii) /BRN= 106294/;

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → (4S)-4-Methyl-1-<(S)-1'-phenylethyl>-4-(2''-thienylmethyl)-2-imidazolin-5-on (65484-52-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / triphenylphosphane, triethylamine, CCl₄ / acetonitrile / 1) 5 h, room temperature, 2) 12 h, room temperature

2: 1) butyllithium / 1) THF, -70 deg C, hexane, 10 min, 2) THF

With tetrachloromethane; n-butyllithium; triethylamine; triphenylphosphine; In acetonitrile;

Reference yield:

2-Isocyano-N-(1-phenyl-ethyl)-propionamide (65484-40-4) → (4S)-4-Methyl-1-<(S)-1'-phenylethyl>-4-(2''-thienylmethyl)-2-imidazolin-5-on (65484-52-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 1) butyllithium / 1) THF, -70 deg C, hexane, 10 min, 2) THF, room temperature, 48 h

2: 50percent NaOH, benzyltriethylammoniumchloride / CH₂Cl₂ / 2 h / Ambient temperature

3: 1) gaseous HCl, 2) HCl / methanol; H₂O / 1) 24 h, reflux, 2) 24 h, reflux

4: 60 percent / triphenylphosphane, triethylamine, CCl₄ / acetonitrile / 1) 5 h, room temperature, 2) 12 h, room temperature

5: 1) butyllithium / 1) THF, -70 deg C, hexane, 10 min, 2) THF

With hydrogenchloride; tetrachloromethane; sodium hydroxide; n-butyllithium; N-benzyl-N,N,N-triethylammonium chloride; triethylamine; triphenylphosphine; In methanol; dichloromethane; water; acetonitrile;

upstream raw materials:

2-Chloromethylthiophene

2-Isocyan-N-<(S)-1'-phenylethyl>propionsaeureamid

(S)-1-phenyl-ethylamine

2-Isocyano-N-(1-phenyl-ethyl)-propionamide