(4R)-3-[(2S)-S-Benzoyl-3-mercapto-2-methylpropanoyl]-2-(2-thienyl)-4-thiazolidinecarboxylic acid

Base Information

• Chemical Name: (4R)-3-[(2S)-S-Benzoyl-3-mercapto-2-methylpropanoyl]-2-(2-thienyl)-4-thiazolidinecarboxylic acid
• CAS No.: 72678-60-5
• Molecular Formula: C₁₉H₁₉NO₄S₃
• Molecular Weight: 421.562
• Mol file: 72678-60-5.mol

Synonyms:(4R)-3-[(2S)-S-Benzoyl-3-mercapto-2-methylpropanoyl]-2-(2-thienyl)-4-thiazolidinecarboxylic acid

Chemical Property of (4R)-3-[(2S)-S-Benzoyl-3-mercapto-2-methylpropanoyl]-2-(2-thienyl)-4-thiazolidinecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (4R)-3-[(2S)-S-Benzoyl-3-mercapto-2-methylpropanoyl]-2-(2-thienyl)-4-thiazolidinecarboxylic acid

There total 2 articles about (4R)-3-[(2S)-S-Benzoyl-3-mercapto-2-methylpropanoyl]-2-(2-thienyl)-4-thiazolidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2RS,4R)-2-(thiophen-2-yl)thiazolidine-4-carboxylic acid (201942-94-1) + (+/-)-S-benzoyl-3-mercapto-2-methylpropanoic acid + isobutyl chloroformate (543-27-1) → (4R)-3-[(2S)-S-Benzoyl-3-mercapto-2-methylpropanoyl]-2-(2-thienyl)-4-thiazolidinecarboxylic acid (72678-60-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; water;

Reference yield:

(2RS,4R)-2-(thiophen-2-yl)thiazolidine-4-carboxylic acid (201942-94-1) + (2S)-3-(benzoylthio)-2-methylpropionic acid (72679-02-8) → (4R)-3-[(2S)-S-Benzoyl-3-mercapto-2-methylpropanoyl]-2-(2-thienyl)-4-thiazolidinecarboxylic acid (72678-60-5)

Guidance literature:

With triethylamine; isobutyl chloroformate; Yield given. Multistep reaction; 1) tetrahydrofuran, RT, 10 min, 2) water, RT, 30 min;

DOI:10.1248/cpb.30.440

upstream raw materials:

(2RS,4R)-2-(thiophen-2-yl)thiazolidine-4-carboxylic acid

(2S)-3-(benzoylthio)-2-methylpropionic acid

isobutyl chloroformate