(S,R)-1-phenyl-2-(1-methyoxy-1-trifluoromethyl-1-phenylacetyl)imino-4-phenyl imidazolidine

Base Information

Chemical Name:(S,R)-1-phenyl-2-(1-methyoxy-1-trifluoromethyl-1-phenylacetyl)imino-4-phenyl imidazolidine
CAS No.:1393707-51-1
Molecular Formula:C₂₅H₂₂F₃N₃O₂
Molecular Weight:453.464
Hs Code.:

Synonyms:(S,R)-1-phenyl-2-(1-methyoxy-1-trifluoromethyl-1-phenylacetyl)imino-4-phenyl imidazolidine

Suppliers and Price of (S,R)-1-phenyl-2-(1-methyoxy-1-trifluoromethyl-1-phenylacetyl)imino-4-phenyl imidazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S,R)-1-phenyl-2-(1-methyoxy-1-trifluoromethyl-1-phenylacetyl)imino-4-phenyl imidazolidine

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Technology Process of (S,R)-1-phenyl-2-(1-methyoxy-1-trifluoromethyl-1-phenylacetyl)imino-4-phenyl imidazolidine

There total 2 articles about (S,R)-1-phenyl-2-(1-methyoxy-1-trifluoromethyl-1-phenylacetyl)imino-4-phenyl imidazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1393670-45-5
(R)-1,4-diphenyl-2-iminoimidazolidine hydrochloride

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 1393707-51-1
(S,R)-1-phenyl-2-(1-methyoxy-1-trifluoromethyl-1-phenylacetyl)imino-4-phenyl imidazolidine

Guidance literature:: With pyridine; dmap; In dichloromethane; at 45 ℃; for 2.5h;
DOI:10.1016/j.tetlet.2012.06.042

Reference yield:

: 1037587-67-9
N-tert-butoxycarbonyl-N’-phenylthiourea

: 1393707-51-1
(S,R)-1-phenyl-2-(1-methyoxy-1-trifluoromethyl-1-phenylacetyl)imino-4-phenyl imidazolidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; mercury dichloride / dichloromethane / 17 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 20 °C

2.2: 0.5 h / 0 °C

3.1: hydrogenchloride / 1,4-dioxane / 3.5 h / 55 °C / Inert atmosphere

4.1: pyridine; dmap / dichloromethane / 2.5 h / 45 °C

With pyridine; hydrogenchloride; dmap; sodium hydride; triethylamine; mercury dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; mineral oil;
DOI:10.1016/j.tetlet.2012.06.042