1-{(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-[2,2,2-trichloro-1,1-bis-(4-methoxy-phenyl)-ethoxy]-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-{(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-[2,2,2-trichloro-1,1-bis-(4-methoxy-phenyl)-ethoxy]-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione
• CAS No.: 174870-95-2
• Molecular Formula: C₃₇H₅₁Cl₃N₂O₉Si₂
• Molecular Weight: 830.35

Synonyms:1-{(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-[2,2,2-trichloro-1,1-bis-(4-methoxy-phenyl)-ethoxy]-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione

Chemical Property of 1-{(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-[2,2,2-trichloro-1,1-bis-(4-methoxy-phenyl)-ethoxy]-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione

Chemical Property:

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Technology Process of 1-{(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-[2,2,2-trichloro-1,1-bis-(4-methoxy-phenyl)-ethoxy]-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione

There total 3 articles about 1-{(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-[2,2,2-trichloro-1,1-bis-(4-methoxy-phenyl)-ethoxy]-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

1,1-dianisyl-2,2,2-trichloroethyl chloride (101119-50-0) + 3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine (69304-38-7) → 1-{(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-[2,2,2-trichloro-1,1-bis-(4-methoxy-phenyl)-ethoxy]-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione (174870-95-2)

Guidance literature:

With 2,3,5-trimethyl-pyridine; 3 A molecular sieve; silver(I) 4-methylbenzenesulfonate; In toluene; for 120h;

DOI:10.1016/0040-4020(95)00981-7

Reference yield:

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) → 1-{(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-[2,2,2-trichloro-1,1-bis-(4-methoxy-phenyl)-ethoxy]-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione (174870-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / pyridine / 16 h / Ambient temperature

2: 61 percent / 3A molecular sieves, collidine, silver p-toluenesulfonate / toluene / 120 h

With pyridine; 2,3,5-trimethyl-pyridine; 3 A molecular sieve; silver(I) 4-methylbenzenesulfonate; In toluene;

DOI:10.1016/0040-4020(95)00981-7

Reference yield:

uridine (58-96-8) → 1-{(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-[2,2,2-trichloro-1,1-bis-(4-methoxy-phenyl)-ethoxy]-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione (174870-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / pyridine / 16 h / Ambient temperature

2: 61 percent / 3A molecular sieves, collidine, silver p-toluenesulfonate / toluene / 120 h

With pyridine; 2,3,5-trimethyl-pyridine; 3 A molecular sieve; silver(I) 4-methylbenzenesulfonate; In toluene;

DOI:10.1016/0040-4020(95)00981-7

upstream raw materials:

1,1-dianisyl-2,2,2-trichloroethyl chloride

3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

uridine

Downstream raw materials:

Diisopropyl-phosphoramidous acid 2-cyano-ethyl ester (2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-4-[2,2,2-trichloro-1,1-bis-(4-methoxy-phenyl)-ethoxy]-tetrahydro-furan-3-yl ester

1-{(2R,3R,4R,5R)-4-Hydroxy-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-3-[2,2,2-trichloro-1,1-bis-(4-methoxy-phenyl)-ethoxy]-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione

1-{(2R,3R,4R,5R)-4-Hydroxy-5-hydroxymethyl-3-[2,2,2-trichloro-1,1-bis-(4-methoxy-phenyl)-ethoxy]-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione

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