(3aR,4R,6S,7S,7aR)-4-[(benzyloxy)methyl]-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran

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Chemical Name:(3aR,4R,6S,7S,7aR)-4-[(benzyloxy)methyl]-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran
CAS No.:863554-28-3
Molecular Formula:C₂₅H₃₂O₇
Molecular Weight:444.525
Hs Code.:

Synonyms:(3aR,4R,6S,7S,7aR)-4-[(benzyloxy)methyl]-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran

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Chemical Property of (3aR,4R,6S,7S,7aR)-4-[(benzyloxy)methyl]-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran

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Technology Process of (3aR,4R,6S,7S,7aR)-4-[(benzyloxy)methyl]-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran

There total 5 articles about (3aR,4R,6S,7S,7aR)-4-[(benzyloxy)methyl]-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 863554-22-7
methyl 6-O-benzyl-3,4-O-isopropylidene-α-D-altropyranoside

: 2746-25-0
p-Methoxybenzyl bromide

: 863554-28-3
(3aR,4R,6S,7S,7aR)-4-[(benzyloxy)methyl]-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran

Guidance literature:: methyl 6-O-benzyl-3,4-O-isopropylidene-α-D-altropyranoside; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

p-Methoxybenzyl bromide; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1002/hlca.200590099

Reference yield:

: 863554-21-6
methyl 2-O-allyl 6-O-benzyl-α-D-altropyranoside

: 863554-28-3
(3aR,4R,6S,7S,7aR)-4-[(benzyloxy)methyl]-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran

Guidance literature:: Multi-step reaction with 3 steps

1.1: 81 percent / TsOH / acetone / 1 h

2.1: 1,4-diazabicyclo[2.2.2]octane; [RhCl(Ph₃P)3] / ethanol; benzene; H₂O / 18 h / Heating

2.2: 85 percent / mercury(II) oxide; mercury(II) chloride / acetone; H₂O / 0.5 h

3.1: NaH / dimethylformamide / 0.25 h / 0 °C

3.2: 95 percent / dimethylformamide / 0 - 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; tris(triphenylphosphine)rhodium(I) chloride; sodium hydride; toluene-4-sulfonic acid; In ethanol; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1002/hlca.200590099

Reference yield:

: 863554-40-9
methyl 2-O-allyl 6-O-benzyl-3,4-O-isopropylidene-α-D-altropyranoside

: 863554-28-3
(3aR,4R,6S,7S,7aR)-4-[(benzyloxy)methyl]-tetrahydro-6-methoxy-7-[(4-methoxybenzyl)oxy]-2,2-dimethyl-4H-1,3-dioxolo[4,5-c]pyran

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,4-diazabicyclo[2.2.2]octane; [RhCl(Ph₃P)3] / ethanol; benzene; H₂O / 18 h / Heating

1.2: 85 percent / mercury(II) oxide; mercury(II) chloride / acetone; H₂O / 0.5 h

2.1: NaH / dimethylformamide / 0.25 h / 0 °C

2.2: 95 percent / dimethylformamide / 0 - 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; tris(triphenylphosphine)rhodium(I) chloride; sodium hydride; In ethanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1002/hlca.200590099