Benzoic acid (4S,5S)-2,2-dimethyl-5-((E)-pentadec-1-enyl)-[1,3]dioxolan-4-ylmethyl ester

Base Information

• Chemical Name: Benzoic acid (4S,5S)-2,2-dimethyl-5-((E)-pentadec-1-enyl)-[1,3]dioxolan-4-ylmethyl ester
• CAS No.: 163379-21-3
• Molecular Formula: C₂₈H₄₄O₄
• Molecular Weight: 444.655
• Mol file: 163379-21-3.mol

Synonyms:Benzoic acid (4S,5S)-2,2-dimethyl-5-((E)-pentadec-1-enyl)-[1,3]dioxolan-4-ylmethyl ester

Chemical Property of Benzoic acid (4S,5S)-2,2-dimethyl-5-((E)-pentadec-1-enyl)-[1,3]dioxolan-4-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid (4S,5S)-2,2-dimethyl-5-((E)-pentadec-1-enyl)-[1,3]dioxolan-4-ylmethyl ester

There total 4 articles about Benzoic acid (4S,5S)-2,2-dimethyl-5-((E)-pentadec-1-enyl)-[1,3]dioxolan-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Benzoic acid (4S,5S)-2,2-dimethyl-5-((Z)-pentadec-1-enyl)-[1,3]dioxolan-4-ylmethyl ester (163212-18-8) → Benzoic acid (4S,5S)-2,2-dimethyl-5-((E)-pentadec-1-enyl)-[1,3]dioxolan-4-ylmethyl ester (163379-21-3)

Guidance literature:

With diphenyl sulfide; In 1,4-dioxane; cyclohexane; for 6h; Irradiation;

DOI:10.1016/S0040-4020(01)89265-6

Reference yield:

(n-tetradecyl)triphenylphosphonium bromide (25791-20-2) → Benzoic acid (4S,5S)-2,2-dimethyl-5-((E)-pentadec-1-enyl)-[1,3]dioxolan-4-ylmethyl ester (163379-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi, 2.) benzoyl chloride / 1.) THF, -78 deg C, 1 h, 2.) THF, room temperature, 4 h

2: 90 percent / phenyl sulfide / cyclohexane; dioxane / 6 h / Irradiation

With n-butyllithium; diphenyl sulfide; benzoyl chloride; In 1,4-dioxane; cyclohexane;

DOI:10.1016/S0040-4020(01)89265-6

Reference yield:

(-)-(S,S)-2,2-dimethyl-1,3-dioxolane-4,5-dimethanol monobenzoate (77398-79-9) → Benzoic acid (4S,5S)-2,2-dimethyl-5-((E)-pentadec-1-enyl)-[1,3]dioxolan-4-ylmethyl ester (163379-21-3)

Guidance literature:

Multi-step reaction with 3 steps

1: CrO₃, pyridine / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) n-BuLi, 2.) benzoyl chloride / 1.) THF, -78 deg C, 1 h, 2.) THF, room temperature, 4 h

3: 90 percent / phenyl sulfide / cyclohexane; dioxane / 6 h / Irradiation

With pyridine; chromium(VI) oxide; n-butyllithium; diphenyl sulfide; benzoyl chloride; In 1,4-dioxane; dichloromethane; cyclohexane;

DOI:10.1016/S0040-4020(01)89265-6

upstream raw materials:

Benzoic acid (4S,5S)-2,2-dimethyl-5-((Z)-pentadec-1-enyl)-[1,3]dioxolan-4-ylmethyl ester

(n-tetradecyl)triphenylphosphonium bromide

(-)-(S,S)-2,2-dimethyl-1,3-dioxolane-4,5-dimethanol monobenzoate

(+)-(4R-trans)-5-<(benzoyloxy)methyl>-2,2-dimethyl-1,3-dioxolane-4-carboxaldehyde