{(1S,2R)-2,3-Dihydroxy-1-[5-(2-methoxy-ethoxymethoxy)-2-nitro-phenyl]-propyl}-carbamic acid benzyl ester

Base Information

Chemical Name:{(1S,2R)-2,3-Dihydroxy-1-[5-(2-methoxy-ethoxymethoxy)-2-nitro-phenyl]-propyl}-carbamic acid benzyl ester
CAS No.:850559-82-9
Molecular Formula:C₂₁H₂₆N₂O₉
Molecular Weight:450.445
Hs Code.:

Synonyms:{(1S,2R)-2,3-Dihydroxy-1-[5-(2-methoxy-ethoxymethoxy)-2-nitro-phenyl]-propyl}-carbamic acid benzyl ester

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Chemical Property of {(1S,2R)-2,3-Dihydroxy-1-[5-(2-methoxy-ethoxymethoxy)-2-nitro-phenyl]-propyl}-carbamic acid benzyl ester

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Technology Process of {(1S,2R)-2,3-Dihydroxy-1-[5-(2-methoxy-ethoxymethoxy)-2-nitro-phenyl]-propyl}-carbamic acid benzyl ester

There total 4 articles about {(1S,2R)-2,3-Dihydroxy-1-[5-(2-methoxy-ethoxymethoxy)-2-nitro-phenyl]-propyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 654644-20-9
(2R,3S)-3-Benzyloxycarbonylamino-2-hydroxy-3-[5-(2-methoxy-ethoxymethoxy)-2-nitro-phenyl]-propionic acid ethyl ester

: 850559-82-9
{(1S,2R)-2,3-Dihydroxy-1-[5-(2-methoxy-ethoxymethoxy)-2-nitro-phenyl]-propyl}-carbamic acid benzyl ester

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1002/anie.200462298

Reference yield:

: 654644-18-5
5-((2-methoxy)ethoxymethoxy)-2-nitrobenzaldehyde

: 850559-82-9
{(1S,2R)-2,3-Dihydroxy-1-[5-(2-methoxy-ethoxymethoxy)-2-nitro-phenyl]-propyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 0 °C

1.2: 94 percent / tetrahydrofuran / 6 h / 0 °C

2.1: 79 percent / NaOH; t-butyl hypochlorite; (DHQ)2PHAL / potassium osmate dihydrate / propan-1-ol; H₂O / 2 h / 0 °C

3.1: 70 percent / LiBH₄ / tetrahydrofuran / 0 - 20 °C

With sodium hydroxide; lithium borohydride; Hydroquinone 1,4-phthalazinediyl diether; tert-butylhypochlorite; sodium hydride; potassium osmate(VI); In tetrahydrofuran; propan-1-ol; water; 2.1: Sharpless aminohydroxylation;
DOI:10.1002/anie.200462298

Reference yield:

: 654644-19-6
(E)-3-[5-(2-Methoxy-ethoxymethoxy)-2-nitro-phenyl]-acrylic acid ethyl ester

: 850559-82-9
{(1S,2R)-2,3-Dihydroxy-1-[5-(2-methoxy-ethoxymethoxy)-2-nitro-phenyl]-propyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / NaOH; t-butyl hypochlorite; (DHQ)2PHAL / potassium osmate dihydrate / propan-1-ol; H₂O / 2 h / 0 °C

2: 70 percent / LiBH₄ / tetrahydrofuran / 0 - 20 °C

With sodium hydroxide; lithium borohydride; Hydroquinone 1,4-phthalazinediyl diether; tert-butylhypochlorite; potassium osmate(VI); In tetrahydrofuran; propan-1-ol; water; 1: Sharpless aminohydroxylation;
DOI:10.1002/anie.200462298